血清VEGF、AQP4、CTRP9对视网膜静脉阻塞患者继发黄斑水肿的预测价值  

Predictive value of serum VEGF,AQP4 and CTRP9 on secondary macular edema in patients with retinal vein obstruction

作　　者：彭琪 解鹏亮 PENG Qi;XIE Pengliang(Tangshan Vocational and Technical College Affiliated Hospital Ophthalmology,Hebei Tangshan 063000,China)

机构地区：[1]唐山职业技术学院附属医院眼科,河北唐山063000

出　　处：《中国实验诊断学》2025年第2期131-135,共5页Chinese Journal of Laboratory Diagnosis

基　　金：河北省2023年度医学科学研究课题计划项目(20231819)。

摘　　要：目的探究血清血管内皮生长因子(VEGF)、水通道蛋白4(AQP4)、C1q肿瘤坏死因子相关蛋白9(CTRP9)水平对视网膜静脉阻塞(RVO)患者继发黄斑水肿的预测价值。方法回顾性选取2023年1月至2023年12月间唐山职业技术学院附属医院164例RVO患者,均采集外周血,用酶联免疫吸附法测定血清VEGF、AQP4、CTRP9水平。根据患者有无发生黄斑水肿将其分为发生组(55例)和未发生组(109例)。收集两组临床资料并进行比较,分析继发黄斑水肿的影响因素,受试者工作特征(ROC)曲线分析VEGF、AQP4、CTRP9的预测价值。结果发生组VEGF、AQP4、甘油三酯(TG)、总胆固醇(TC)、糖化血红蛋白(HbA1c)高于未发生组,CTRP9低于未发生组(P<0.05)。Logistic结果显示,VEGF水平(OR=4.386,95%CI:1.922~10.010)、AQP4水平(OR=3.669,95%CI:1.903~7.074)、CTRP9水平(OR=0.217,95%CI:0.102~0.463)、TG水平(OR=1.877,95%CI:1.232~2.861)、HbA1c水平(OR=2.301,95%CI:1.345~3.937)是RVO患者继发黄斑水肿的独立影响因素(P<0.05)。ROC显示,VEGF、AQP4、CTRP9及其三者联合预测RVO患者继发黄斑水肿的灵敏度分别为72.70%、74.50%、78.20%、90.90%,特异度分别为78.00%、69.70%、65.10%、87.20%,曲线下面积(AUC)分别为0.814、0.783、0.786、0.909(P<0.05)。结论VEGF、AQP4是RVO患者继发黄斑水肿的独立危险因素,CTRP9是独立保护因素,三者联合进行检测可较好的预测黄斑水肿发生风险。Objective To investigate the predictive value of serum vascular endothelial growth factor(VEGF),aqua-porin 4(AQP4)and Clq tumor necrosis factor-related protein 9(CTRP9)levels for secondary macular edema in pa-tients with retinal vein occlusion(RVO).Methods A total of 164 patients with RVO in our hospital from January 2023 to December 2023 were retrospectively selected.Peripheral blood was collected from all patients,and serum VEGF,AQP4 and CTRP9 levels were measured by enzyme-linked immunosorbent assay.The patients were divided into the oc-currence group(55 cases)and the non-occurrence group(109 cases)according to the presence or absence of macular e-dema.The clinical data of the two groups were collected and compared,and the influencing factors of secondary macular edema were analyzed.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of VEGF,AQP4 and CTRP9.Results The levels of VEGF,AQP4,triglyceride(TG),total cholesterol(TC)and glycosy-lated hemoglobin(HbAlc)in the occurrence group were higher than those in the non-occurrence group,and CTRP9 was lower than that in the non-occurrence group(P<0.05).Logistic regression analysis showed that VEGF level(OR=4.386,95%CI:1.922~10.010),AQP4level(OR=3.669,95%CI:1.903~7.074),CTRP9level(OR=0.217,95%CI:0.102~0.463),TG level(OR=1.877,95%CI:1.232~2.861)and HbA1clevel(OR=2.301,95%CI:1.345~3.937)were the independent influencing factors of secondary macular edema in RVO patients(P<0.05).ROC analysis showed that the sensitivity of VEGF,AQP4,CTRP9 and their combination to predict secondary macular edema in pa-tients with RVO were 72.70%,74.50%,78.20%and 90.90%,respectively,and the specificity were 78.00%,69.70%,65.10%and 87.20%,respectively,and the area under the curve(AUC)were 0.814,0.783,0.786 and 0.909,respectively(P<0.05).Conclusion VEGF and AQP4 are independent risk factors for secondary macular edema in pa-tients with RVO,and CTRP9 is an independent protective factor.The combined detection of the three factors can better predict the risk

关 键 词：视网膜静脉阻塞 黄斑水肿 血管内皮生长因子 水通道蛋白4 C1q肿瘤坏死因子相关蛋白9 预测价值 

分 类 号：R774.1[医药卫生—眼科]