天然活性成分抑制皮肤胶原蛋白流失的研究进展  

Research progress of natural bioactive products in resisting loss of skin collagen

作　　者：胡楚涓 王璐璐[1] 蒋建东[1] 李瑞 HU Chu-juan;WANG Lu-lu;JIANG Jian-dong;LI Rui(Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)

机构地区：[1]中国医学科学院、北京协和医学院医药生物技术研究所,北京100050

出　　处：《药学学报》2025年第2期269-279,共11页Acta Pharmaceutica Sinica

基　　金：中国工程院战略研究与咨询项目(2023-ZX-88);中国医学科学院医学与健康科技创新工程(2022-I2M-1-016)。

摘　　要：皮肤是人体最大的器官,也是人体抵抗外界侵害的第一道屏障。胶原蛋白是皮肤的重要组成部分,皮肤胶原蛋白的流失不仅影响皮肤的美观,同时损伤皮肤健康并影响正常功能的行使,寻找延缓皮肤衰老与抑制胶原蛋白流失的方法具有重要意义。皮肤胶原流失的发生机制复杂、影响因素多样,天然活性成分具有多靶点、多途径的特点,在治疗皮肤胶原蛋白流失中具有独特优势。本文对皮肤中胶原蛋白流失的机制及天然活性成分通过促进胶原蛋白合成抗皮肤衰老的研究进展进行综述,以期为相关研究提供参考。As the biggest tissue of human body,skin is the first barrier of resisting external aggression.Collagen is one of important parts of the skin,which could not only affect the aesthetics of skin,but also influence the health and normal function of skin.It is the great significance to find ways that could inhibit the loss of collagen.The mechanisms of the collagen degradation in skin are complex and multifaceted.Natural bioactive products have unique advantages in treating the loss of collagen,which have multi-targets and mechanisms.In this review,the mechanisms of skin collagen degradation are discussed,and the research progress of natural bioactive products in resisting skin aging through promoting collagen synthesis are reviewed,in order to provide references for futural research.

关 键 词：胶原蛋白 天然活性成分 皮肤衰老 线粒体 

分 类 号：R966[医药卫生—药理学]