恶性黑色素瘤前哨淋巴结定位技术  

Sentinel lymph node perioperative mapping in malignant melanoma

作　　者：张雨欣 刘天一 Zhang Yuxin;Liu Tianyi(Department of Plastic Surgery,Huadong Hospital,Fudan University,Shanghai 200040,China)

机构地区：[1]复旦大学附属华东医院整形外科,上海200040

出　　处：《中华整形外科杂志》2025年第1期74-80,共7页Chinese Journal of Plastic Surgery

基　　金：上海市"科技创新行动计划"医学创新研究专项(22Y11905800)。

摘　　要：恶性黑色素瘤(MM)是一种起源于皮肤黑色素细胞,常伴早期淋巴转移的侵袭性皮肤恶性肿瘤。前哨淋巴结(SLN)是肿瘤淋巴转移的第一站引流淋巴结。前哨淋巴结活组织检查(SLNB)是MM分期过程中的关键性步骤,准确定位和SLN微转移的识别能够指导后续治疗决策,是一个重要的预后因素。该文强调了标准技术的创新,包括术前淋巴闪烁显像技术和术中放射性示踪法和蓝染料示踪法等。此外,该文还总结了新型示踪剂和显像技术,以期指导SLNB在MM患者中的临床应用。Malignant melanoma,which originates from skin melanocytes,is an extremely aggressive and often lethal malignant skin cancer with early lymphatic metastasis.Sentinel lymph nodes(SLNs)are a group of lymph nodes initially involved in the metastasis.Sentinel lymph node biopsy(SLNB)is a decisive step in the staging process of melanoma and limits the extent of the dissection in negative nodes.Thus,accurately identifying and mapping the micrometastasis in SLNs represents an important prognostic factor.This review highlights the innovation of standard technique entails a preoperative lymphoscintigraphy and an intraoperative mapping using a radiotracer and a blue dye.Moreover,this review summarize the different novel tracers,preoperative and intraoperative imaging modalities assisting SLNB in malignant melanoma as supplements or alternatives to the traditional protocol.

关 键 词：黑色素瘤 前哨淋巴结 前哨淋巴结活组织检查 淋巴转移 淋巴定位 

分 类 号：R739.5[医药卫生—肿瘤]