浅表CD34阳性纤维母细胞肿瘤2例及文献复习  

Superficial CD34-positive fibroblastic tumor:report of two cases and review of the literatures

作　　者：张睿 苏哲人 龙俊桑 吕仁荣[2,3] 毕见海 霍然 Zhang Rui;Su Zheren;Long Junsang;Lyu Renrong;Bi Jianhai;Huo Ran(Cheeloo College of Medicine,Shandong University,Jinan 250063,China;Department of Burn and Plastic Surgery,Shandong Provincial Hospital,Jinan 250021,China;Department of Burn and Plastic Surgery,Shandong Provincial Hospital Affiliated to Shandong First Medical University,Jinan 250021,China)

机构地区：[1]山东大学齐鲁医学院,济南250063 [2]山东省立医院烧伤整形美容外科,济南250021 [3]山东第一医科大学附属省立医院烧伤整形美容外科,济南250021

出　　处：《中华整形外科杂志》2025年第1期81-86,共6页Chinese Journal of Plastic Surgery

基　　金：国家自然科学基金(82172227)。

摘　　要：该文报道了2022和2023年山东省立医院收治的2例浅表CD34阳性纤维母细胞肿瘤(SCPFT)患者的临床表现、病理学特征、免疫表型及随访情况,并结合相关文献进行讨论。2例患者均为男性,年龄分别为43及20岁,肿瘤分别位于会阴部及左肩背部,均表现为单个缓慢生长的皮下肿物,病程以年计,无疼痛、瘙痒,但伴有轻度压痛。镜下主要表现为肿瘤性梭形、上皮样细胞、多形性核细胞呈片状及束状排列。免疫表型:1例CD34弥漫强阳性,1例CD34部分阳性。2例均于该院行扩大切除手术,保证边、底切缘阴性,分别随访22、12个月,未见复发。该文通过复习相关文献对SCPFT的临床特点、病理及鉴别诊断进行了讨论和总结。SCPFT是一种新型纤维母细胞性肿瘤,属低度恶性软组织肿瘤,具有独特的病理及生物学表现,临床上较为罕见,常规切除极易复发,需长期随访,结合形态学特征及免疫组化有助于诊断。该疾病需与其他肿瘤相鉴别,以防止误诊误治。This paper reported the clinical manifestations,pathological features,immunophenotype and follow-up of two patients with superficial CD34-positive fibroblastic tumor(SCPFT),who were admitted to Shandong Provincial Hospital in 2022 and 2023,and discussed the relevant literatures.The two patients,aged 43 and 20 years old,were both male.Their tumors were located in the perineum and the back of left shoulder,respectively.Both presented as single slow-growing subcutaneous masses with a course typically measured in years,accompanied by mild tenderness but without pain or pruritus.Microscopically,spindled to epithelioid cells and pleomorphous nuclear cells arranged in cellular fascicles and solid sheets were the main findings.Immunophenotypically,positive expression of CD34 was found in both cases.Extended resection ensured negative marginal and basal margins for both cases.No recurrence was observed after 22 and 12 months of follow-up,respectively.Clinical features,pathology,and differential diagnosis were discussed and summarized through a review of relevant literature.SCPFT is a novel type of fibroblastic tumor categorized as a low-grade malignant soft tissue tumor with unique pathological and biological characteristics that is relatively rare clinically.Routine resection may lead to recurrence;therefore,long-term follow-up is necessary.The combination of morphological characteristics and immunohistochemistry is helpful to diagnosis.It is important to differentiate this disease from other tumors to avoid misdiagnosis or mistreatment.

关 键 词：皮肤肿瘤 纤维母细胞肿瘤 CD34阳性 免疫组织化学 诊断 鉴别 

分 类 号：R739.5[医药卫生—肿瘤]