早发性精神分裂症静息态脑功能连接研究新进展  

New progress in the research of resting state brain functional connectivity in early-onset schizophrenia

作　　者：申晴晴 夏磊[1,2] 郝明茹 刘寰忠 Shen Qingqing;Xia Lei;Hao Mingru;Liu Huanzhong(Psychiatry Department,Chaohu Hospital of Anhui Medical University,Hefei 238000,China;Anhui Provincial Mental Health Center,Hefei 238000,China;School of Mental Health and Psychological Science,Anhui Medical University,Hefei 238000,China;Anhui Provincial Key Laboratory for Brain Bank Construction and Resource Utilization,Hefei 238000,China)

机构地区：[1]安徽医科大学附属巢湖医院精神科,合肥238000 [2]安徽省精神医学中心,合肥238000 [3]安徽医科大学精神卫生与心理科学学院,合肥238000 [4]脑库构建及资源利用安徽省重点实验室,合肥238000

出　　处：《神经疾病与精神卫生》2025年第2期77-82,共6页Journal of Neuroscience and Mental Health

基　　金：2022年安徽省转化医学研究院科研基金(2022zhyx-B01);安徽省高等学校科学研究项目(2022AH050671);2019年度国家临床重点专科能力建设项目(皖财社[2019]1166号);2022年度新时代育人质量工程项目(2022gjxslt010)。

摘　　要：近年来的观点认为,精神分裂症是一种脑功能连接障碍,而功能连接是指大脑不同区域之间低频波动的统计时间相关性。早发性精神分裂症作为一种严重的精神疾病,同样存在着脑功能连接的改变,但其与脑功能连接的关系仍不明确,因此一直是近些年研究的热点。静息态脑功能情况反映了大脑在静息状态下的活动模式。随着脑功能连接分析方法的不断进步,静息态脑网络功能连接为了解和识别精神分裂症、建立精神分裂症的诊断模型、提高患者的预后提供了重要的技术支撑。本文对静息态脑网络功能连接、早发性精神分裂症患者脑功能连接的改变以及脑功能连接与早发性精神分裂症患者核心症状的相关性进行综述,为了解早发性精神分裂症的生理机制及寻找治疗靶点提供思路和参考。In recent years,it has been considered that schizophrenia is a disorder of brain functional connectivity.The functional connectivity refers to the statistical temporal correlation of low-frequency fluctuations between different regions of the brain.As a serious mental disease,early-onset schizophrenia also has changes in brain function connection.However,the relationship between early-onset schizophrenia and brain function connection is still not clear,making it a hot research topic in recent years.The resting state of brain function reflects the pattern of brain activity in a resting state.With the continuous advancement of brain functional connectivity analysis methods,the functional connectivity of resting brain network provides important technical support for understanding and identifying schizophrenia,establishing diagnostic models of schizophrenia,and improving the prognosis of patients.This article aims to review the changes in resting-state brain network functional connectivity and brain functional connectivity in early-onset schizophrenia,as well as the correlation between brain functional connectivity and core symptoms in early-onset schizophrenia,in order to provide ideas and references for understanding the physiological mechanism of early-onset schizophrenia and exploring therapeutic targets.

关 键 词：静息状态 脑功能连接 早发性精神分裂症 核心症状 综述 

分 类 号：R749.3[医药卫生—神经病学与精神病学]