急性应激对小鼠神经行为影响及相关机制的研究进展  

Research progress on the effects and underlying mechanisms of acute stress on mouse neurobehavior

作　　者：江丽芳 王齐媛 罗南芳 柳涛[1] Jiang Lifang;Wang Qiyuan;Luo Nanfang;Liu Tao(Department of Pediatrics,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第一附属医院儿科,330006

出　　处：《神经疾病与精神卫生》2025年第2期131-136,共6页Journal of Neuroscience and Mental Health

基　　金：国家自然科学基金(32060186)。

摘　　要：急性应激反应是生物体应对突发环境压力的短暂适应性反应,旨在恢复生理和行为的稳态平衡。它常在事件发生后即刻出现,并可在数小时至数天内迅速消退。急性应激作用于机体的生理、心理和行为层面,与多种心理疾病(如焦虑症等)风险的增加有关。小鼠模型的研究在揭示急性应激相关疾病的发生机制方面扮演着关键角色。因此,本文对近年来关于急性应激对小鼠神经行为影响及其相关生物学机制的文献进行梳理和综述,旨在为急性应激的干预策略提供理论依据。The acute stress response is a transient adaptive response of an organism to a sudden environmental stress,aimed at rebuilding physiological and behavioral homeostasis.It often appears immediately after the event and can subside rapidly within hours to days.Acute stress acts on the physiological,psychological,and behavioral aspects of the organism and is associated with an increased risk for a variety of psychological disorders(such as anxiety disorders).Studies in mouse models play a key role in unraveling the mechanisms underlying the acute stress-related diseases.This paper compiles and reviews the literature on the effects of acute stress on neurobehavior and its related biological mechanisms in mice in recent years,aiming to provide a theoretical basis for the intervention of acute stress.

关 键 词：急性应激 动物模型 神经行为 机制 综述 

分 类 号：R749.5[医药卫生—神经病学与精神病学]