阿尔茨海默病神经炎症损伤中miRNA介导TLR4信号通路的作用机制及其中西医防治的研究进展  

Mechanism of miRNA-mediated TLR4 signaling pathway in neuroinflammatory injury in Alzheimer disease and its research progress on Chinese and western medicine prevention and treatment

作　　者：张汝希 易亚乔 刘涛阳 谭润章 孙媛 邝振威 彭玺如 高晨 Zhang Ruxi;Yi Yaqiao;Liu Taoyang;Tan Runzhang;Sun Yuan;Kuang Zhenwei;Peng Xiru;Gao Chen(School of Medicine,Hunan University of Chinese Medicine,Changsha 410208,China;School of Traditional Chinese Medicine,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学医学院,长沙410208 [2]湖南中医药大学中医学院,长沙410208

出　　处：《神经疾病与精神卫生》2025年第2期144-152,共9页Journal of Neuroscience and Mental Health

基　　金：湖南省大学生创新创业训练计划项目(S202210541124);湖南省教育厅科研基金重点项目(22A0262);湖南省卫生健康委科研项目(202203105682);湖南省中医药科研基金项目(D2022104);2022年第五批全国中医临床优秀人才研修项目(国中医药人教函[2022]239号);2022年度湖南中医药大学校级科研项目(2022XJZKA002);2023年度大学本科生科研创新基金项目(2023BKS018)。

摘　　要：阿尔茨海默病(AD)是一种严重威胁老年人群健康的神经系统疾病,发病率逐年上升,尚无治愈方法。因此,深入研究致病机制并寻求防治策略意义重大。神经炎症被认为是AD的重要病理特征与病因,微RNA(miRNA)可影响Toll样受体4(TLR4)信号通路的上、中、下游相关因子,调节机体神经炎性水平。大量研究表明,miRNA以及TLR4信号通路在神经炎症中发挥重要作用,其中miR-34a-5p、miR-107-5p和miR-146a等几种特异性miRNA可靶向TLR4信号通路,参与AD的神经炎症损伤。本文重点关注miRNA如何通过调控TLR4信号通路影响AD的神经炎症损伤,并总结针对这一信号通路的中西医治疗途径,以期为AD防治提供新思路。Alzheimer's disease(AD)is a neurological disorder that poses a serious threat to the health of the elderly population,with the incidence increasing every year and no cure available.It is of great significance to conduct in-depth research on the pathogenic causative mechanisms and to seek preventive and curative strategies.Neuroinflammation is considered to be an important pathological feature and cause of AD,and microRNAs(miRNAs)can affect upstream,midstream,and downstream factors associated with the Toll-like receptor 4(TLR4)signaling pathway to regulate the level of neuroinflammation in the body.Numerous studies have shown that miRNAs as well as the TLR4 signaling pathway play important roles in neuroinflammation,and several specific miRNAs,including miR-34a-5p,miR-107-5p,and miR-146a,can target the TLR4 signaling pathway and participate in neuroinflammatory injury in AD.This paper focuses on how miRNAs affect neuroinflammatory injury in AD by regulating the TLR4 signaling pathway,and summarizes the Chinese and Western medicine treatment pathways targeting this signaling pathway,with a view to providing new ideas for AD prevention and treatment.

关 键 词：阿尔茨海默病 MIRNA TLR4 神经炎症 中西医结合治疗 综述 

分 类 号：R749.16[医药卫生—神经病学与精神病学]