脂溶性维生素5风险及其严重程度的预测效能研究项联合MHR对子痫前期  

Predictive Efficacy of Five Lipid-soluble Vitamins Combined with MHR for Preeclampsia and Its Severity

作　　者：张琪 冯园 周梅英 石玉琴[1] Zhang Qi;Feng Yuan;Zhou Meiying;Shi Yuqin(School of Medicine,Wuhan University of Science and Technology,Wuhan,Hubei 430081;Wuhan Chain Medical Labs,Wuhan,Hubei 430000)

机构地区：[1]武汉科技大学医学院,湖北武汉430081 [2]武汉千麦医学检验实验室,湖北武汉430000

出　　处：《科技与健康》2025年第2期1-4,共4页Technology and Health

摘　　要：探析脂溶性维生素5项、单核细胞/高密度脂蛋白水平评估子痫前期(preeclampsia,PE)风险及病情的预测价值。纳入2021年5月—2024年5月至武汉科技大学医学院进行孕检的251例孕妇为研究对象,根据是否罹患PE将其划分为PE组与非PE组,测定孕妇脂溶性维生素5项[25羟基维生素D(25(OH)D)、25(OH)D2、25(OH)D3、维生素A(VA)、维生素E(VE)]、MHR水平,分析相关指标与PE发生风险及病情的关系。结果表明,PE组25(OH)D、25(OH)D3、VA、VE水平低于非PE组,25(OH)D2、MHR水平高于非PE组,重度PE较轻度PE更明显(P<0.05)。Spearman相关性分析结果显示:25(OH)D、25(OH)D3、VA、VE、MHR与PE风险及病情均相关,25(OH)D2与PE风险相关(P<0.05)。研究发现,PE孕妇多伴有25(OH)D3、VA、VE和MHR指标异常,其水平对PE发生风险及病情具有较高的预测效能。To explore the predictive value offive lipid-soluble vitamins and the monocyte to high-density lipoprotein cholesterol ratio(MHR)levels in assessing the risk and condition of preeclampsia(PE).A total of 251 pregnant women who had prenatal examinations in the School of Medicine of Wuhan University of Science and Technology from May 2021 to May 2024 were included as the research objects.They were divided into the PE group and the non-PE group according to whether they had PE.The levels offive lipid-soluble vitamins[25-hydroxyvitamin D(25(OH)D),25(OH)D2,25(OH)D3,vitamin A(VA),vitamin E(VE)]and MHR of the pregnant women were measured,and the relationships between the relevant indicators and the risk of PE and the disease condition were analyzed.The results showed that the levels of 25(OH)D,25(OH)D3,VA,and VE in the PE group were lower than those in the non-PE group,while the levels of 25(OH)D2 and MHR were higher than those in the non-PE group,and this was more obvious in severe PE than in mild PE(P<0.05).The results of Spearman correlation analysis showed that 25(OH)D,25(OH)D3,VA,VE,and MHR were all correlated with the risk and condition of PE,and 25(OH)D2 was correlated with the risk of PE(P<0.05).The study found that pregnant women with PE are mostly accompanied by abnormal indicators of 25(OH)D3,VA,VE,and MHR,and their levels have a high predictive efficacy for the risk of PE occurrence and the disease condition.

关 键 词：子痫前期 脂溶性维生素 单核细胞/高密度脂蛋白胆固醇 预测效能 

分 类 号：R734.2[医药卫生—肿瘤]