血清CXCL10联合CXCL12检测对急性胰腺炎患者预后的预测价值  

Predictive value of serum CXCL10 and CXCL12 for prognosis of patients with acute pancreatitis

作　　者：祖渭东 许博 胡晓红 Zu Weidong;Xu Bo;Hu Xiaohong(Department of Clinical Laboratory,Weinan Second Hospital,Weinan 714000,China)

机构地区：[1]渭南市第二医院检验科,渭南714000

出　　处：《国际医药卫生导报》2025年第6期1036-1040,共5页International Medicine and Health Guidance News

基　　金：陕西省重点研发计划(2024SF-YBXM-172)。

摘　　要：目的探讨血清CXC趋化因子配体(CXC chemokine ligand,CXCL)10联合CXCL12检测对急性胰腺炎(acute pancreatitis,AP)患者预后的预测价值。方法选取2021年3月至2024年5月在渭南市第二医院收治的120例AP患者作为研究对象(AP组),其中男69例、女51例,年龄(54.47±7.12)岁;选择同期来院体检的120名健康者设为对照组,其中男66例、女54例,年龄(53.48±6.26)岁。将AP患者按病情严重程度分为轻症组78例和重症组42例,根据治疗1个月后的结果分为预后良好组99例和预后不良组21例。采用酶联免疫吸附测定法检测患者血清CXCL10和CXCL12水平,并通过多因素logistic回归分析评估影响AP患者预后的因素,受试者操作特征曲线(ROC)分析CXCL10和CXCL12联合检测对AP患者预后的预测效能。采用t检验、χ^(2)检验或Fisher确切概率法进行统计比较。结果AP组血清CXCL10、CXCL12水平高于对照组[(178.80±34.71)μg/L比(90.29±10.14)μg/L、(2.71±0.65)μg/L比(1.65±0.23)μg/L],差异均有统计学意义(t=26.813、16.841,均P<0.05)。重症组血清CXCL10、CXCL12水平高于轻症组[(201.20±38.83)μg/L比(166.74±31.90)μg/L、(2.98±0.74)μg/L比(2.56±0.62)μg/L],差异均有统计学意义(t=5.224、3.304,均P<0.05)。预后不良组血清CXCL10、CXCL12水平高于预后良好组[(216.42±41.10)μg/L比(170.82±33.55)μg/L、(3.13±0.78)μg/L比(2.62±0.60)μg/L],差异均有统计学意义(t=5.432、3.348,均P<0.05)。多因素logistic回归分析表明,血清CXCL10、CXCL12均为影响AP患者预后的独立危险因素(均P<0.05)。ROC显示,CXCL10联合CXCL12预测灵敏度、特异度分别为90.5%、88.9%,AUC为0.944,均高于单独检测(均P<0.05)。结论血清CXCL10联合CXCL12检测对急性胰腺炎患者预后的预测具有较高的临床应用价值。Objective To investigate the predictive value of serum CXC chemokine ligand 10(CXCL10)and CXC chemokine ligand 12(CXCL12)for prognosis of patients with acute pancreatitis(AP).Methods A total of 120 patients with AP treated at Weinan Second Hospital from March 2021 to May 2024 were selected as an AP group,including 69 males and 51 females who were(54.47±7.12)years old.Additionally,120 healthy individuals undergoing physical examinations at Weinan Second Hospital during the same period were selected as a control group,including 66 males and 54 females who were(53.48±6.26)years.The patients were categorized by severity into a mild group(78 cases)and a severe group(42 cases),and were divided into a good prognosis group(99 cases)and a poor prognosis group(21 cases)based on the 1-month treatment outcomes.The serum CXCL10 and CXCL12 levels were measured by the enzyme linked immunosorbent assay.The multivariate logistic regression analysis was performed to assess the factors influencing the patients'prognosis.The predictive performance of CXCL10 and CXCL12 for the patients'prognosis was analyzed using the receiver operating characteristic curves(ROC).Statistical analysis was conducted using t andχ²tests or Fisher's precision probability test.Results The serum levels of CXCL10 and CXCL12 in the AP group were higher than those in the control group[(178.80±34.71)μg/L vs.(90.29±10.14)μg/L and(2.71±0.65)μg/L vs.(1.65±0.23)μg/L],with statistical differences(t=26.813 and 16.841;both P<0.05).The serum levels of CXCL10 and CXCL12 in the severe group were higher than those in the mild group[(201.20±38.83)μg/L vs.(166.74±31.90)μg/L and(2.98±0.74)μg/L vs.(2.56±0.62)μg/L],with statistical differences(t=5.224 and 3.304;both P<0.05).The serum levels of CXCL10 and CXCL12 in the poor prognosis group were higher than those in the good prognosis group[(216.42±41.10)μg/L vs.(170.82±33.55)μg/L and(3.13±0.78)μg/L vs.(2.62±0.60)μg/L],with statistical differences(t=5.432 and 3.348;both P<0.05).The multivariate logist

关 键 词：急性胰腺炎 CXC趋化因子配体10 CXC趋化因子配体12 预测 

分 类 号：R576[医药卫生—消化系统]