基于非编码RNA的针灸基础研究进展  

Progress in Basic Research on Acupuncture and Moxibustion Based on Non-coding RNA

作　　者：魏荧 熊坚 李萧 胡金群 赵燚 孙雨欣 凌发样 刘渝 杨丽源 梁繁荣[1] 齐文川 WEI Ying;XIONG Jian;LI Xiao;HU Jinqun;ZHAO Yi;SUN Yuxin;LING Fayang;LIU Yu;YANG Liyuan;LIANG Fanrong;QI Wenchuan(College of Acupuncture-Moxibustion and Tuina,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China)

机构地区：[1]成都中医药大学针灸推拿学院,四川成都610075

出　　处：《中国中医药信息杂志》2025年第3期174-179,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金联合基金(U21A20404);国家自然科学基金面上项目(82074556);国家自然科学基金青年科学基金(82205286);中国博士后科学基金(2020M683642XB);四川省自然科学基金(2023NSFSC1819)。

摘　　要：针灸疗法是我国具有原创性优势的治疗保健方法。随着表观遗传学和系统生物学技术的迅速发展,非编码RNA(ncRNA)相关研究在针灸领域不断取得突破。本文整理ncRNA相关的针灸基础研究文献,对微小RNA(miRNA)、长链非编码RNA(lncRNA)和环状RNA(circRNA)相关研究分系统进行综述,ncRNA广泛参与机体的生长、发育、生殖及各疾病的发生发展过程,与针灸疗法多层次、多途径、多靶点的作用网络相契合。以ncRNA为切入点深入探索针灸作用机制,不仅有利于促进针灸效应新靶点的挖掘,还能揭示针灸效应分子的表观遗传调控轴,为疾病的临床诊疗和疗效评估提供思路和方法。Acupuncture and moxibustion therapy is a kind of treatment and health care method with original advantages of China.With the rapid development of epigenetics and systems biology technology,non-coding RNA(ncRNA)related research has made continuous breakthroughs in the field of acupuncture and moxibustion.This article collected the basic research literature on acupuncture and moxibustion related to ncRNA,and reviewed the research subsystems related to microRNA(miRNA),long chain non coding RNA(lncRNA)and circular RNA(circRNA).NcRNAs are widely involved in the growth,development and reproduction of the organism,as well as in the occurrence and development of various diseases,which fits with the multi-layer,multi-pathway and multi-target action network of acupuncture and moxibustion therapy.Taking ncRNAs as the breakthrough point to explore the mechanism of acupuncture and moxibustion in depth is not only conducive to promoting the exploration of new targets of acupuncture and moxibustion effect,but also can reveal the epigenetic regulation axis of acupuncture and moxibustion effect molecules,and provide ideas and methods for clinical diagnosis and treatment of diseases and evaluation of efficacy.

关 键 词：非编码RNA 针灸 分子机制 表观遗传学 系统生物学 综述 

分 类 号：R245[医药卫生—针灸推拿学]