血清Fibulin-5、Pannexin1水平对一氧化碳中毒并发急性脑梗死患者预后的预测价值  

Predictive value of serum Fibulin-5 and Pannexin 1 levels on prognosis of patients with carbon monoxide poisoning complicated by acute cerebral infarction

作　　者：黄莺 刘亚泽 Huang Ying;Liu Yaze(Emergency Room of Internal Medicine,Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010000,China)

机构地区：[1]内蒙古医科大学附属医院急诊内科,呼和浩特010000

出　　处：《心脑血管病防治》2025年第1期17-20,共4页CARDIO-CEREBROVASCULAR DISEASE PREVENTION AND TREATMENT

摘　　要：目的分析血清中衰老关键蛋白抗原-5(Fibulin-5)、泛连接蛋白1(Pannexin1)水平与一氧化碳(CO)中毒并发急性脑梗死(ACI)的关系及其对预后的预测价值。方法选取2019年1月至2022年12月内蒙古医科大学附属医院收治的178例CO中毒患者为研究对象,根据CO中毒后60 d内是否并发ACI分为非ACI组133例和ACI组45例,ACI组患者依据随访结果分为预后良好组32例和预后不良组13例。采用酶联免疫吸附试验检测血清中Fibulin-5和Pannexin1表达水平;采用多因素Cox回归分析并发ACI患者预后的影响因素;采用ROC曲线分析血清中Fibulin-5和Pannexin1表达水平对并发ACI患者预后的预测价值。结果非ACI组和ACI组血清中Fibulin-5和Pannexin1表达水平比较,差异有统计学意义(t=2.789、5.751,P<0.05);与预后良好组比,预后不良组血清中Fibulin-5和Pannexin1表达水平升高,差异有统计学意义(t=4.056、5.008,P<0.05);不同预后并发ACI患者的梗死面积、病情严重程度差异有统计学意义(χ^(2)=7.182、6.689,P<0.05);多因素Cox回归分析结果显示,Fibulin-5和Pannexin1表达水平是影响并发ACI患者预后的因素(HR=4.317、4.861,P<0.05);ROC曲线分析结果显示,血清中Fibulin-5和Pannexin1表达水平联合预测并发ACI患者预后的价值较单一指标预测价值更高(Z=2.071、1.760,P<0.05),敏感度为92.30%,特异度为93.70%。结论CO中毒并发ACI患者血清中Fibulin-5和Pannexin1表达水平升高,可作为预测CO中毒并发ACI患者预后的生物学指标。Objective To analyze the relationships between serum levels of Fibulin-5 and Pannexin 1,and the occurrence of acute cerebral infarction(ACI)in patients with carbon monoxide(CO)poisoning,as well as their predictive value for prognosis.Methods From January 2019 to December 2022,178 patients with CO poisoning admitted to Affiliated Hospital of Inner Mongolia Medical University were selected as the study subjects.According to whether ACI occurred within 60days after CO poisoning,they were divided into non-ACI group(133 cases)and ACI group(45 cases).Based on follow-up results,patients were further divided into good prognosis group(32 cases)and poor prognosis group(13 cases).Enzyme-linked immunosorbent assay was applied to detect serum expression levels of Fibulin-5 and Pannexin 1.Multivariate Cox regression analysis was used to identify factors influencing the prognosis of patients with concurrent ACI.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum Fibulin-5 and Pannexin 1 levels for the prognosis of patients with concurrent ACI.Results The differences of serum levels of Fibulin-5and Pannexin 1 in the non-ACI group and ACI group were statistically significant(t=2.789,5.751;P<0.05).Compared with the good prognosis group,serum levels of Fibulin-5 and Pannexin 1 in the poor prognosis group increased significantly(t=4.056,5.008;P<0.05).In patients with concurrent ACI,different outcomes were associated with infarct size and the severity of the condition(χ^(2)=7.182,6.689;P<0.05).Multivariate Cox regression analysis showed that the expression levels of Fibulin-5 and Pannexin 1 were factors influencing the prognosis of patients with concurrent ACI(HR=4.317,4.861;P<0.05).ROC curve analysis showed that the combined predictive value of serum Fibulin-5 and Pannexin 1 levels for the prognosis of patients with ACI was higher than that of single index(Z=2.071,1.760;P<0.05),with a sensitivity of 92.30%and specificity of 93.70%.Conclusion Serum levels of Fibulin-5 and Pannexin 1 in pa

关 键 词：一氧化碳中毒 急性脑梗死 衰老关键蛋白抗原5 泛连接蛋白1 预后 

分 类 号：R743.33[医药卫生—神经病学与精神病学] R595.1[医药卫生—临床医学]