Ozone exposure and cardiovascular disease:A narrative review of epidemiology evidence and underlying mechanisms  

作　　者：Qiaoyi Hua Xin Meng Jicheng Gong Xinghua Qiu Jing Shang Tao Xue Tong Zhu 

机构地区：[1]SKL-ESPC&SEPKL-AERM,College of Environmental Sciences and Engineering and Center for Environment and Health,Peking University,Beijing 100871,China [2]Institute of Reproductive and Child Health/Ministry of Health Key Laboratory of Reproductive Health and Department of Epidemiology and Biostatistics,School of Public Health,Peking University Health Science Center,Beijing 100871,China

出　　处：《Fundamental Research》2025年第1期249-263,共15页自然科学基础研究(英文版)

基　　金：supported by the National Natural Science Foundation of China(42293324).

摘　　要：Ozone(O_(3))poses a significant global public health concern as it exerts adverse effects on human cardiovascular health.Nevertheless,there remains a lack of comprehensive understanding regarding the relationships between O_(3)exposure and the risk of cardiovascular diseases(CVD),as well as the underlying biological mechanisms.To address this knowledge gap,this narrative review meticulously summarizes the existing epidemiological evidence,susceptibility,and potential underlying biological mechanisms linking O_(3)exposure with CVD.An increasing body of epidemiological studies has demonstrated that O_(3)exposure heightens the incidence and mortality of CVD,including specific subtypes such as ischemic heart disease,hypertension,and heart failure.Certain populations display heightened vulnerability to these effects,particularly children,the elderly,obese individuals,and those with pre-existing conditions.Proposed biological mechanisms suggest that O_(3)exposure engenders respiratory and systemic inflammation,oxidative stress,disruption of autonomic nervous and neuroendocrine systems,as well as impairment of coagulation function,glucose,and lipid metabolism.Ultimately,these processes contribute to vascular dysfunction and the development of CVD.However,some studies have reported the absence of associations between O_(3)and CVD,or even potentially protective effects of O_(3).Inconsistencies among the literature may be attributed to inaccurate assessment of personal O_(3)exposure levels in epidemiologic studies,as well as confounding effects stemming from co-pollutants and temperature.Consequently,our findings underscore the imperative for further research,including the development of reliable methodologies for assessing personal O_(3)exposure,exploration of O_(3)exposure's impact on cardiovascular health,and elucidation of its biological mechanisms.These endeavors will consolidate the causal relationship between O_(3)and cardiovascular diseases,subsequently aiding efforts to mitigate the risks associated with O_(3)expo

关 键 词：Ozone exposure Cardiovascular disease Epidemiologic study Mechanism SUSCEPTIBILITY 

分 类 号：R54[医药卫生—心血管疾病]