牛心包膜在美学区水平骨增量手术中的应用效果分析  

Efficacy analysis of bovine pericardium membrane for horizontal bone augmentation in the aesthetic zone

作　　者：林季萩 莫安春[1] LIN Jiqiu;MO Anchun(Department of Implant Dentistry,West China Hospital of Stomatology,Sichuan University&National Clinical Research Center for Oral Diseases,Chengdu 610041,China)

机构地区：[1]四川大学华西口腔医院种植科、国家口腔疾病临床医学研究中心,四川成都610041

出　　处：《口腔疾病防治》2025年第3期203-211,共9页Journal of Prevention and Treatment for Stomatological Diseases

基　　金：四川省科技厅重点研发项目(2024YFFK0294);四川省卫健委项目(19ZD008)。

摘　　要：目的探讨牛心包膜在美学区水平骨增量手术中的应用效果,评估其在引导骨再生术(guided bone regeneration,GBR)中的临床可行性。方法本研究通过医院医学伦理委员会审查批准。29例前牙区缺牙伴唇侧骨缺损的患者,应用牛心包膜结合颗粒状或块状骨移植物进行水平骨增量手术。以术前设计中的虚拟种植体为中心,测量术前(T0)、术后即刻(T1)及术后6个月(T2)不同时期种植体颈部及其以下1~5 mm处种植体唇侧骨板厚度,评估骨再生效果。记录术后患者的疼痛、肿胀视觉模拟评分(visual analog scale,VAS),以及是否有感染、伤口裂开等并发症发生。结果术后即刻,所有患者种植体唇侧骨板厚度显著增加,平均骨增量大于3 mm;术后6个月,骨增量保持较好,特别是在种植体颈部下方3~5 mm处唇侧骨板厚度均大于3 mm。VAS评分显示,术后疼痛及肿胀在术后3 d达到峰值,随后逐渐减轻,术后10 d恢复良好。随访期间无感染、伤口裂开等并发症发生。结论牛心包膜在美学区水平骨增量中具有良好的骨增量效果和生物相容性。Objective To investigate the application effect of bovine pericardium in horizontal bone augmentation surgery in the aesthetic area and to assess its clinical feasibility in guided bone regeneration(GBR).Methods This study was approved by the Ethics Committee.A total of 29 patients with anterior tooth loss accompanied by labial bone defects were selected,and horizontal bone augmentation was performed using a bovine pericardium membrane combined with particulate or block bone grafts.Centered on the virtual implant in the preoperative design,labial bone thickness at the implant neck and 1-5 mm below it was measured at different time points:preoperatively(T0),immediately postopera-tively(T1),and 6 months postoperatively(T2).The results were used to assess bone regeneration outcomes.Additional-ly,the visual analog scales(VASs)of postoperative pain and swelling were recorded,and whether any complications such as infection or wound dehiscence occurred were monitored.Results Immediately after surgery,labial bone thick-ness of all implants significantly increased,with an average increase more than 3 mm.Six months after surgery,the bone augmentation was well maintained.Specifically,labial bone thickness 3-5 mm below the shoulder of the implant was greater than 3 mm.The VAS scores showed that postoperative pain and swelling peaked on the third day and then gradually decreased,with good recovery 10 days after surgery.No complications such as infection or wound dehiscence occurred during the follow-up period.Conclusion Bovine pericardium shows good bone augmentation effect and bio-compatibility in horizontal bone augmentation in the anterior aesthetic area,and it is suitable for various horizontal bone augmentation surgeries in the aesthetic area.

关 键 词：牛心包膜 胶原膜 引导骨再生术 水平骨增量 美学区 唇侧骨板厚度 并发症 

分 类 号：R78[医药卫生—口腔医学]