低分子量肝素钙联合胰岛素治疗对高脂血症性胰腺炎患者生化指标和炎性因子的影响  

Effect of Low Molecular Weight Heparin Calcium Combined with Insulin Therapy on Biochemical Indicators and Inflammatory Factors in Patients with Hyperlipidemia Pancreatitis

作　　者：方聪 盛锦义 FANG Cong;SHENG Jinyi(Jingdezhen First People's Hospital,Jingdezhen Jiangxi 333000,China)

机构地区：[1]景德镇市第一人民医院,江西景德镇333000

出　　处：《药品评价》2024年第10期1260-1263,共4页Drug Evaluation

基　　金：江西省卫生健康委科技计划项目(20220867)。

摘　　要：目的探讨低分子量肝素钙联合胰岛素治疗对高脂血症性胰腺炎(HLAP)患者生化指标和炎性因子的影响。方法选取于2021年6月至2023年12月被景德镇市第一人民医院收治的100例HLAP患者,用随机数字表法分两组,每组各50例。对照组单用胰岛素治疗,观察组在对照组基础上联合低分子量肝素钙治疗,治疗时间为5 d。对比两组临床疗效,生化指标[总胆固醇(TG)、甘油三酯(TG)、淀粉酶(AMY)],炎性因子[C反应蛋白(CRP)、白细胞计数(WBC)],凝血指标[血浆D-二聚体(D-D)、抗凝血酶-Ⅲ(AT-Ⅲ)、纤维蛋白原(FIB)、凝血酶原时间(PT)]及不良反应。结果观察组临床疗效为96.00%(48/50),高于对照组的80.00%(40/50),差异有统计学意义(P<0.05)。对比两组治疗前生化指标、炎性因子、凝血指标,差异无统计学意义(P>0.05);治疗后,观察组TG、TC、MAY、CRP、WBC、D-D、FIB水平均较对照组低,AT-Ⅲ、PT水平均较对照组高,差异有统计学意义(P<0.05)。两组不良反应比较,差异无统计学意义(P>0.05)。结论低分子量肝素钙与胰岛素联合使用,能有效提高HLAP患者的临床疗效,显著改善患者生化指标、炎性因子水平及凝血指标,且不良反应少,安全性较好。Objective To investigate the effect of the combination of low molecular weight heparin calcium and insulin on biochemical indicators and inflammatory factors in patients with hyperlipidemia pancreatitis(HLAP).Methods 100 HLAP patients were selected,all were admitted to Jingdezhen First People's Hospital from June 2021 to December 2023,and divided into 2 groups by random number table,with 50 patients in each group.The control group was treated with insulin alone,and the observation group combined with low molecular weight heparin calcium therapy on the basis of the control group,were treated with 5 d.Compared with clinical efficacy,biochemical indexes[total cholesterol(TG),triglyceride(TG),amylase(AMY)],inflammatory factors[C reactive protein(CRP),white blood cell count(WBC)],coagulation indexes[plasma D-dimer(D-D),antithrombin-Ⅲ(AT-Ⅲ),fibrinogen(FIB),prothrombin time(PT)]and adverse reactions.Results The clinical efficacy of the observation group was 96.00%(48/50),which was higher than the 80.00%(40/50)in the control group,the difference was statistically significant(P<0.05).There was no significant difference in biochemical indexes,inflammatory factors and coagulation indexes between the two groups before treatment(P>0.05);after treatment,TG,TC,MAY,CRP,WBC,D-D and FIB levels in the observation group were lower than those in the control group,and AT-Ⅲand PT levels were higher than the control group,the differences were statistically significant(P<0.05).The adverse effects of the two groups,difference were not statistically significant(P>0.05).Conclusion The combination of low molecular weight heparin calcium and insulin can effectively improve the clinical efficacy of HLAP patients,significantly improve the biochemical index,inflammatory factor levels and coagulation index of patients,with few adverse reactions and good safety.

关 键 词：高脂血症性胰腺炎 低分子量肝素钙 胰岛素 生化指标 炎性因子 

分 类 号：R576[医药卫生—消化系统]