不同时长亚低温治疗对动脉取栓术患者神经功能、生活质量及脑出血情况的影响  

Effects of different durations of mild hypothermia therapy on neurological function, quality of life and cerebral hemorrhage in patients undergoing arterial thrombectomy

作　　者：齐立 王琳 唐超坤 赵永波 黄惠媛 QI Li;WANG Lin;TANG Chaokun;ZHAO Yongbo;HUANG Huiyuan(Neurological Department,the 924th Hospital of the PLA Joint Logistics Support Force,Guilin 541000,China;Rehabilitation Medicine Department,the 924th Hospital of the PLA Joint Logistics Support Force,Guilin 541000,China)

机构地区：[1]中国人民解放军联勤保障部队第九二四医院神经内科,广西桂林541000 [2]中国人民解放军联勤保障部队第九二四医院康复医学科,广西桂林541000

出　　处：《临床医学研究与实践》2025年第6期37-40,共4页Clinical Research and Practice

基　　金：广西壮族自治区卫生健康委自筹经费科研课题(No.Z-C20241562);桂林市科学研究与技术开发计划项目(No.20220139-1-2)。

摘　　要：目的 探讨不同时长亚低温治疗对动脉取栓术患者神经功能、生活质量及脑出血情况的影响。方法 选择2022年12月至2024年5月我院接诊的116例急性缺血性脑卒中患者作为研究对象,采用随机化法以1∶1∶1∶1的比例将患者分为对照组(术后未进行亚低温治疗)、A组(术后持续灌注4℃生理盐水20 min)、B组(术后持续灌注4℃生理盐水40 min)和C组(术后持续灌注4℃生理盐水60 min),每组29例。比较四组患者治疗前及治疗1、3、7 d后的美国国立卫生研究院卒中量表(NIHSS)评分;比较四组患者治疗后90 d的改良Rankin量表(m RS)评分;记录并比较四组患者治疗期间脑出血发生情况。结果 治疗3、7 d后,四组的NIHSS评分低于治疗前(P<0.05);治疗3、7 d后,C组的NIHSS评分显著低于对照组、A组及B组(P<0.05)。四组患者的生活质量良好占比比较,差异具有统计学意义(P<0.05);C组的生活质量良好占比高于对照组、A组和B组(P<0.05)。四组患者的脑出血发生率比较,差异具有统计学意义(P<0.05);B组、C组的脑出血发生率低于对照组(P<0.05),其中C组的最低。结论 动脉取栓术后实施60 min的亚低温治疗能改善急性缺血性脑卒中患者的神经功能和生活质量,降低脑出血风险。Objective To investigate the effects of different durations of mild hypothermia therapy on neurological function,quality of life and cerebral hemorrhage in patients undergoing arterial thrombectomy.Methods A total of 116 patients with acute ischemic stroke who were admitted in our hospital from December 2022 to May 2024 were selected as the research objects.The patients were randomly divided into control group(no mild hypothermia therapy after operation),group A(continuous perfusion of 4℃normal saline for 20 min after operation),group B(continuous perfusion of 4℃normal saline for 40 min after operation)and group C(continuous perfusion of 4℃normal saline for 60 min after operation)in a ratio of 1∶1∶1∶1,with 29 cases in each group.The National Institute of Health Stroke Scale(NIHSS)score of the four groups before treatment and 1,3 and 7 d after treatment were compared;the Modified Rankin Scale(mRS)score at 90 d after treatment were compared among the four groups;the incidence of cerebral hemorrhage during treatment was recorded and compared among the four groups.Results After 3 and 7 d of treatment,the NIHSS score of the four groups was lower than that before treatment(P<0.05);after 3 and 7 d of treatment,the NIHSS score of the group C was significantly lower than that of the control group,the group A and the group B(P<0.05).There was statistically significant difference in the proportion of patients with good quality of life in the four groups(P<0.05);the proportion of good quality of life in the group C was higher than that in the control group,the group A and the group B(P<0.05).There was statistically significant difference in the incidence of cerebral hemorrhage among the four groups(P<0.05);the incidence of cerebral hemorrhage in the group B Mild hypothermia therapy for 60 min after arterial thrombectomy can improve the neurological function and quality of life of patients with acute ischemic stroke, and reduce the risk of cerebral hemorrhage.

关 键 词：急性缺血性脑卒中 动脉取栓术 亚低温治疗 治疗时长 

分 类 号：R743.33[医药卫生—神经病学与精神病学]