基于双联抗血小板方案的Solitaire AB支架介入治疗急性缺血性脑卒中的效果及对脑摄氧、神经功能的影响  

Effect of Solitaire AB stent intervention based on dual antiplatelet regimen on acute ischemic stroke and its influences on cerebral oxygen uptake and neurological function

作　　者：曹军霞 席江波 CAO Junxia;XI Jiangbo(the First People's Hospital of Xianyang,Xianyang 712000,China)

机构地区：[1]咸阳市第一人民医院,陕西咸阳712000

出　　处：《临床医学研究与实践》2025年第6期77-80,共4页Clinical Research and Practice

摘　　要：目的 探究基于双联抗血小板方案的Solitaire AB支架介入治疗急性缺血性脑卒中(AIS)的效果及对脑摄氧、神经功能的影响。方法 选择2021年1月至2023年2月我院收治的120例AIS患者为研究对象,以随机数字表法将其分为对照组和观察组,每组60例。对照组接受静脉溶栓联合双联抗血小板方案治疗,观察组给予基于双联抗血小板方案的Solitaire AB支架介入治疗。比较两组的血管再通情况、脑摄氧指标及神经功能。结果 观察组的血管再通率为96.67%,高于对照组的85.00%,差异具有统计学意义(P<0.05)。治疗后,观察组的动脉血氧含量(CaO_(2))、动静脉血氧含量差[D(a-jv)O_(2)]水平及脑氧摄取率(CERO_(2))均低于对照组,差异具有统计学意义(P<0.05)。治疗后,观察组的脑源性神经营养因子(BDNF)、神经生长因子(NGF)水平高于对照组,胶质纤维酸性蛋白(GFAP)水平及美国国立卫生研究院卒中量表(NIHSS)评分低于对照组,差异具有统计学意义(P<0.05)。结论 基于双联抗血小板方案的Solitaire AB支架介入治疗AIS,可提高血管再通率,改善患者的脑摄氧及神经功能,值得推广。Objective To explore the effect of Solitaire AB stent intervention based on dual antiplatelet regimen in the treatment of acute ischemic stroke(AIS)and its influences on cerebral oxygen uptake and neurological function.Methods A total of 120 patients with AIS admitted in our hospital from January 2021 to February 2023 were selected as the research objects and divided into control group and observation group by random number table method,with 60 cases in each group.The control group was treated with intravenous thrombolysis combined with dual antiplatelet regimen,and the observation group was treated with Solitaire AB stent intervention based on dual antiplatelet regimen.The vascular recanalization,cerebral oxygen uptake index and neurological function were compared between the two groups.Results The vascular recanalization rate of the observation group was 96.67%,which was higher than 85.00%in the control group,and the difference was statistically significant(P<0.05).After treatment,the levels of arterial oxygen(CaO_(2)),arterial venous oxygen content difference[D(a-jv)O_(2)]and cerebral extraction of oxygen(CERO_(2))in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of brain derived neurotrophic factor(BDNF)and nerve growth factor(NGF)in the observation group were higher than those in the control group,the level of glial fibrillary acidic protein(GFAP)and the National Institutes of Health Stroke Scale(NIHSS)score were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Solitaire AB stent intervention based on dual antiplatelet regimen for AIS can improve vascular recanalization rate,ameliorate cerebral oxygen uptake and neurological function of patients,which is worthy of promotion.

关 键 词：双联抗血小板方案 Solitaire AB支架介入 急性缺血性脑卒中 脑摄氧 神经功能 

分 类 号：R743.34[医药卫生—神经病学与精神病学]