宫腔镜手术联合孕激素治疗早期子宫内膜癌和不典型增生的效果及对妊娠结局的影响  

Effect of hysteroscopy combined with progesterone in the treatment of early endometrial cancer and atypical hyperplasia and its influence on pregnancy outcome

作　　者：刘桂萍 LIU Guiping(Xi'an Aerospace General Hospital,Xi'an 710100,China)

机构地区：[1]西安航天总医院,陕西西安710100

出　　处：《临床医学研究与实践》2025年第6期81-84,共4页Clinical Research and Practice

摘　　要：目的 探讨宫腔镜手术联合孕激素治疗早期子宫内膜癌和不典型增生的效果及对妊娠结局的影响。方法 选取2021年12月至2022年3月西安航天总医院收治的90例早期子宫内膜癌和不典型增生患者为研究对象,以随机数字表法将其分为对照组和观察组,各45例。对照组给予孕激素治疗,观察组给予宫腔镜手术联合孕激素治疗。比较两组的治疗效果。结果 观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的雌二醇(E2)、促卵泡生成素(FSH)及促黄体生成素(LH)低于对照组(P<0.05)。治疗后,观察组的白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平均低于对照组(P<0.05)。观察组的1年内成功受孕率为88.57%(31/35),高于对照组的62.96%(17/27)(P<0.05);观察组的妊娠结局优于对照组(P<0.05)。结论 宫腔镜手术联合孕激素治疗早期子宫内膜癌和不典型增生可提高临床效果,调节雌激素指标水平,也能下调机体炎症反应,提高1年内成功受孕率,改善妊娠结局,值得推广。Objective To investigate the effect of hysteroscopy combined with progesterone in the treatment of early endometrial cancer and atypical hyperplasia and its influence on pregnancy outcome.Methods A total of 90 patients with early endometrial cancer and atypical hyperplasia admitted in Xi'an Aerospace General Hospital from December 2021 to March 2022 were selected as the research objects.The patients were divided into control group and observation group by random number table method,with 45 cases in each group.The control group was treated with progesterone,and the observation group was treated with hysteroscopy combined with progesterone.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the estradiol(E2),follicle stimulating hormone(FSH)and luteinizing hormone(LH)in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of interleukin-1β(IL-1β),interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)in the observation group were lower than those in the control group(P<0.05).The successful pregnancy rate within 1 year in the observation group was 88.57%(31/35),which was higher than 62.96%(17/27)in the control group(P<0.05);the pregnancy outcome of the observation group was better than that of the control group(P<0.05).Conclusion Hysteroscopy combined with progesterone in the treatment of early endometrial cancer and atypical hyperplasia can improve the clinical effect,regulate the level of estrogen index,down-regulate the inflammatory response of the body,elevate the successful pregnancy rate within 1 year,and ameliorate the pregnancy outcome,which is worthy of promotion.

关 键 词：宫腔镜手术 孕激素 子宫内膜癌 子宫内膜不典型增生 

分 类 号：R737.33[医药卫生—肿瘤]