术前CONUT评分联合血清CEA对胸腔镜非小细胞肺癌根治术患者的预后预测分析  

Prognostic analysis of preoperative CONUT score combined with serum CEA in patients undergoing thoracoscopic radical resection of non-small cell lung cancer

作　　者：雷涛 Lei Tao(Hospital,Joint Logistic Support Force,Chinese People’s Liberation Army,Yantai,Shandong 264000,China)

机构地区：[1]中国人民解放军联勤保障部队第九七〇医院,山东烟台264000

出　　处：《首都食品与医药》2025年第1期32-35,共4页Capital Food Medicine

摘　　要：目的分析术前控制营养状态评分(Controlling Nutritional Status Score,CONUT)联合血清癌胚抗原(Carcinoembryonic Antigen,CEA)对胸腔镜非小细胞肺癌根治术患者的预后预测价值。方法回顾性分析中国人民解放军联勤保障部队第九七〇医院2022年1月-2023年12月收治的148例非小细胞肺癌(Non-Small Cell Lung Cancer,NSCLC)患者临床资料,所有患者均行胸腔镜非小细胞肺癌根治术,根据患者预后情况将其分为预后不良组(n=42)与预后良好组(n=106),比较两组患者一般资料、术前CONUT评分、血清CEA水平,采用Logistic回归分析影响患者预后的危险因素,采用受试者工作特征(receiver operationcurve,ROC)曲线评估术前CONUT评分、血清CEA对胸腔镜非小细胞肺癌根治术患者的预后预测价值。结果两组患者临床分期、浸润深度、肿瘤直径、治疗方式、CONUT评分、血清CEA等指标比较,差异具有统计学意义(P<0.05)。多因素Logistic回归分析结果显示:临床分期、治疗方式、CONUT评分、血清CEA是影响胸腔镜非小细胞肺癌根治术患者预后的危险因素(P<0.05)。ROC曲线分析CONUT评分、血清CEA联合预测胸腔镜非小细胞肺癌根治术患者预后的AUC为0.982(95%CI:0.964-0.999),灵敏度为91.6%,特异度为94.3%,优于CONUT评分、血清CEA各指标单独预测。结论临床分期、治疗方式、CONUT评分、血清CEA是影响胸腔镜非小细胞肺癌根治术患者预后的危险因素,联合检测CONUT评分、血清CEA可以提供更准确的预测信息,具有较高预测价值。Objective To analyze the Controlling Nutritional Status Score(CONUT)controlling nutritional status score(CONUT)combined with serum Carcinoembryonic Antigen,Prognostic value of CEA in patients undergoing thoracoscopic radical resection of nonsmall cell lung cancer.Methods The clinical data of 148 patients with Non-Small Cell Lung Cancer(NSCLC)in the 970th Hospital of the Chinese People’s Liberation Army Joint Logistics Support Force from January 2022 to December 2023 were retrospectively analyzed.All patients underwent thoracoscopic radical resection of NSCLC.According to the prognosis,patients were divided into poor prognosis group(n=42)and good prognosis group(n=106).General data,preoperative CONUT score and serum CEA level of the two groups were compared,and the risk factors affecting prognosis were analyzed by Logistic regression.Receiver operationcurve(ROC)curve was used to evaluate the prognostic value of preoperative CONUT score and serum CEA in patients undergoing thoracoscopic radical resection of non-small cell lung cancer.Results Comparison of clinical staging,depth of invasion,tumor diameter,treatment modality,CONUT score,and serum CEA between the two groups showed statistically significant differences(P<0.05).Multivariate logistic regression analysis indicated that clinical staging,treatment modality,CONUT score,and serum CEA are risk factors affecting the prognosis of patients undergoing thoracoscopic radical surgery for non-small cell lung cancer(NSCLC)(P<0.05).ROC curve analysis demonstrated that the combined prediction of CONUT score and serum CEA for the prognosis of patients undergoing thoracoscopic radical surgery for NSCLC had an AUC of 0.982(95%CI:0.964-0.999),with a sensitivity of 91.6%and specificity of 94.3%,which was superior to the individual predictions of CONUT score and serum CEA.Conclusion Clinical staging,treatment modality,CONUT score,and serum CEA are risk factors affecting the prognosis of patients undergoing thoracoscopic radical surgery for non-small cell lung cancer(NSCLC).C

关 键 词：CONUT评分 血清CEA 胸腔镜 非小细胞肺癌 肺癌根治术 

分 类 号：R734.2[医药卫生—肿瘤]