大剂量奥曲肽治疗肝硬化合并消化道出血的效果探讨  

Discussion on the effect of high-dose octreotide in the treatment of liver cirrhosis with gastrointestinal bleeding

作　　者：经凯 颜迪 王军平 Jing Kai;Yan Di;Wang Junping(Guanyun County People’s Hospital,Lianyungang,Jiangsu 222200,China)

机构地区：[1]江苏省灌云县人民医院,江苏连云港222200

出　　处：《首都食品与医药》2025年第1期79-81,共3页Capital Food Medicine

摘　　要：目的探究肝硬化合并消化道出血患者应用不同剂量奥曲肽治疗的效果。方法将灌云县人民医院自2021年3月-2023年3月收治的60例肝硬化合并消化道出血患者纳入研究。采用信封法均分为大剂量组和参照组,每组30例。参照组行奥美拉唑联合奥曲肽治疗,大剂量组行奥美拉唑联合大剂量奥曲肽治疗。比较两组临床疗效、临床相关指标、血清指标及不良反应发生情况。结果治疗后,大剂量组临床疗效、临床相关指标、血清指标均优于参照组(P<0.05);两组不良反应发生情况比较,无明显差异(P>0.05)。结论对比常规剂量,大剂量奥曲肽对肝硬化合并消化道出血患者的作用更好,患者临床疗效提高,临床相关指标、血清指标改善,无严重不良反应发生,具有借鉴意义。Objective Explore the effect of different doses of octreotide in the treatment of patients with liver cirrhosis and gastrointestinal bleeding.Methods Sixty patients admitted to Guanyun County People’s Hospital from March 2021 to March 2023 were included in the study.They were equally divided into the high-dose group and the reference group by envelope method,with 30 cases in each group.The reference group was treated with omeprazole combined with octreotide,and the high-dose group was treated with omeprazole combined with high-dose octreotide.The clinical efficacy,clinical related indicators,serum indicators and the occurrence of adverse reactions were compared between the two groups.Results The clinical efficacy,clinical correlation index and serum index in the high-dose group were better than the reference group(P<0.05);the occurrence of adverse reactions between the two groups were compared(P>0.05).Conclusions Compared with the conventional dose,high-dose octreotide has a better effect on patients with liver cirrhosis and gastrointestinal bleeding,improves the clinical efficacy of patients,improves clinical related indicators and serum indicators,and has no serious adverse reactions,which has reference significance.

关 键 词：大剂量奥曲肽 肝硬化 消化道出血 临床指标 不良反应 

分 类 号：R573.2[医药卫生—消化系统]