左旋多巴联合普拉克索治疗帕金森病对患者运动功能的影响评估  

Assessment of the Effect of Levodopa Combined with Pramipexole in Parkinson's Disease on Motor Function

作　　者：范丽华 叶剑鹏[1] 陈一鸣 胡岸 FAN Lihua;YE Jianpeng;CHEN Yiming;HU An(Sanming Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Fujian University of Traditional Chinese Medicine,Sanming,Fujian,365000,China)

机构地区：[1]福建中医药大学附属三明市中西医结合医院,福建三明365000

出　　处：《中外医疗》2024年第36期128-131,共4页China & Foreign Medical Treatment

摘　　要：目的探讨帕金森病治疗中,采取普拉克索+左旋多巴方案的效果。方法选取2022年5月—2023年12月福建中医药大学附属三明市中西医结合医院收治的78例帕金森病患者为研究对象,根据不同用药方案分为对照组、研究组,每组39例。对照组以左旋多巴治疗,研究组联合普拉克索治疗,对比两组的运动功能、氧化应激水平、不良反应。结果治疗1个月、治疗3个月,研究组帕金森综合评分量表Ⅲ评分(30.12±1.21)分、(23.20±1.14)分均低于对照组的(34.39±1.15)分、(27.19±3.27)分,差异均有统计学意义(t=15.974,7.195;P均<0.05)。治疗后,两组超氧化物歧化酶高于治疗前,丙二醛低于治疗前,研究组超氧化物歧化酶高于对照组,丙二醛低于对照组,差异均有统计学意义(P均<0.05)。两组不良反应总发生率对比,差异无统计学意义(P>0.05)。结论帕金森病治疗过程中,采取联合用药的方案,将普拉克索、左旋多巴结合,不仅能够减轻患者受到的氧化应激损伤,而且对促进其运动功能的改善作用较好,不会增加其发生不良反应的风险。Objective To investigate the effect of pramipexole+levodopa regimen in the treatment of Parkinson's disease.Methods A total of 78 patients with Parkinson's disease admitted to Sanming Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Fujian University of Traditional Chinese Medicine from May 2022 to December 2023 were selected as the research objects.According to different medication regimens,they were divided into control group and study group,with 39 cases in each group.The control group was treated with levodopa,and the study group was treated combined with pramipexole.The motor function,oxidative stress level and adverse reactions of the two groups were compared.Results After 1 month and 3 months of treatment,the Unified Parkinson's Disease Rating ScaleⅢscores of motor function in the study group were(30.12±1.21)points and(23.20±1.14)points,which were lower than those in the control group(34.39±1.15)points and(27.19±3.27)points,the differences were statistically significant(t=15.974,7.195;both P<0.05).After treatment,the superoxide dismutase in the two groups was higher than that before treatment,the malondialdehyde was lower than that before treatment,the superoxide dismutase in the study group was higher than that in the control group,and the malondialdehyde was lower than that in the control group,the differences were statistically significant(all P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of Parkinson's disease,the combination of pramipexole and levodopa can not only reduce the oxidative stress injury of patients,but also promote the improvement of their motor function,without increasing the risk of adverse reactions.

关 键 词：帕金森病 普拉克索 左旋多巴 运动功能 氧化应激反应 

分 类 号：R742.5[医药卫生—神经病学与精神病学]