微卫星不稳定性状态对结肠癌患者的临床病理特征及预后的影响  

Effect of microsatellite instability on clinicopathological features and prognosis of colon cancer patients

作　　者：黄根钻 李伟 HUANG Genzuan;LI Wei(Department of Oncology Surgery,Xianyang Hospital Affiliated to Yan'an University,Yanan 712000,China)

机构地区：[1]延安大学咸阳医院肿瘤外科,陕西延安712000

出　　处：《中国肿瘤外科杂志》2025年第1期53-56,共4页Chinese Journal of Surgical Oncology

基　　金：陕西省自然科学基础研究计划资助项目(2020JQ-836)。

摘　　要：目的探究微卫星不稳定性(MSI)状态对结肠癌患者的临床病理特征及预后的影响。方法选取延安大学咸阳医院2018年1月至2020年6月期间诊治的结肠癌患者122例,将结肠癌患者根据微卫星不稳定状态检测结果分为低微卫星不稳定组和高微卫星不稳定组。选取D2S123、D17S250、D5S346、Bat-25以及Bat-26微卫星位点进行检测判断微卫星不稳定状态。记录并分析3年内受试者的生存情况。观察微卫星不稳定状态与结肠癌的病理特征与预后的关系。结果根据微卫星不稳定表达情况,低微卫星不稳定组有78例,高微卫星不稳定组有44例。比较两组的年龄、性别、BMI、家族遗传史、CEA和CA19-9的差异不明显(P>0.05)。比较低微卫星不稳定组和高微卫星不稳定组结肠癌患者的病理特征,结果表明高微卫星不稳定组的肿瘤溃疡型、肿瘤最大直径≥5 cm、TNM分期Ⅰ期、中低分化均高于低微卫星不稳定组(P<0.05)。低微卫星不稳定组完成3年随访的患者为71例,其中有23例(32.4%)患者因肿瘤复发或转移死亡,3年总生存率为67.6%(48/71)。高微卫星不稳定组完成3年随访的患者为43例,其中3例(7.0%)患者因肿瘤复发或转移死亡,3年总生存率为93.0%(40/43)。比较两组3年总生存率,高微卫星不稳定组明显高于低微卫星不稳定组(P<0.05)。结论微卫星不稳定状态对结肠癌患者的病理特征有明显的影响,高微卫星不稳定患者的预后明显优于低微卫星不稳定患者,为评估该病提供参考。Objective To Explore the impact of microsatellite instability status(MSI)on clinicopathological features and prognosis of colon cancer patients.Methods A total of 122 colon cancer patients treated in Xianyang Hospital,Yan'an University were selected and divided into low microsatellite instability group and high microsatellite instability group based on microsatellite instability status detection results.Microsatellite sites D2S123,D17S250,D5S346,Bat-25,and Bat-26 were selected for detection and judgment of microsatellite instability status.To record and analyze the survival status of the subjects within the past 3 years.Observation of the relationship between microsatellite instability status and pathological features and prognosis of colon cancer.Results According to microsatellite instability expression,there were 78 cases in the low microsatellite instability group and 44 cases in the high microsatellite instability group.The differences in age,gender,BMI,family genetic history,CEA,and CA19-9 between the two groups were not significant(P>0.05).Comparing the pathological features of colon cancer patients in low and high microsatellite instability groups,the results showed that the tumor ulcer type,maximum tumor diameter 5 cm,and TNM stagingⅠ,middle and low differentiation the in high microsatellite instability group were higher than those in low microsatellite instability group(P<0.05).A total of 71 patients in the low microsatellite instability group completed a 3-year follow-up,of which 23(32.4%)died due to tumor recurrence or metastasis.The overall 3-year survival rate was 67.6%(48/71).There were 43 patients in the high microsatellite instability group who completed a 3-year follow-up,of which 3(7.0%)died due to tumor recurrence or metastasis.The overall 3-year survival rate was 93.0%(40/43).Comparing the overall 3-year survival rates of two groups,the high microsatellite instability group was significantly higher than the low microsatellite instability group(P<0.05).Conclusions Microsatellite instability

关 键 词：结肠癌 微卫星不稳定状态 病理特征 预后 

分 类 号：R735.35[医药卫生—肿瘤]