非酒精性脂肪性肝病患者合并轻度认知功能障碍的影响因素分析  

Analysis of Influencing Factors of Mild Cognitive Impairment in Patients with Nonalcoholic Fatty Liver Disease

作　　者：刘婵 努日曼古丽·赛麦尔 梁灿灿[1] Liu Chan;Nurimanguli Saimaier;Liang Cancan(The Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,Xinjiang Uygur Autonomous Region,China)

机构地区：[1]新疆医科大学第二附属医院,新疆维吾尔自治区乌鲁木齐830000

出　　处：《中外医药研究》2025年第4期52-54,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:分析非酒精性脂肪性肝病(NAFLD)患者合并轻度认知功能障碍(MCI)的影响因素。方法:选取2024年1—7月就诊于新疆医科大学第二附属医院消化科的350例NAFLD患者作为研究对象,根据是否合并MCI分为MCI组(136例)、非MCI组(214例)。分析两组相关指标,运用Logistic回归模型分析NAFLD患者合并MCI的影响因素。结果:两组性别、糖尿病发生率、高血压发生率、冠心病发生率、体质量指数、收缩压、舒张压、白细胞计数、红细胞计数、天门冬氨酸氨基转移酶水平、碱性磷酸酶水平、谷氨酰转肽酶水平、乳酸脱氢酶水平比较,无统计学差异(P>0.05);MCI组年龄小于非MCI组,血小板计数及丙氨酸氨基转移酶水平高于MCI组(P<0.05)。Logistic回归分析显示,血小板和丙氨酸氨基转移酶水平是NAFLD合并MCI的独立危险因素(P<0.05)。结论:血小板计数、丙氨酸氨基转移酶水平是NAFLD患者合并MCI的独立危险因素,临床应对其开展针对性干预。Objective:To analyze the influencing factors of mild cognitive impairment(MCI)in patients with nonalcoholic fatty liver disease(NAFLD).Methods:A total of 350 NAFLD patients who visited the Department of Gastroenterology at the Second Affiliated Hospital of Xinjiang Medical University from January to July 2024 were enrolled in this study.They were divided into the MCI group(n=136)and the non-MCI group(n=214)based on the presence of MCI.Relevant indicators of the two groups were analyzed,and a logistic regression model was used to identify the influencing factors of NAFLD patients with MCI.Results:There were no significant differences between the two groups in terms of gender,incidence of diabetes,hypertension,coronary heart disease,body mass index,systolic blood pressure,diastolic blood pressure,white blood cell count,red blood cell count,aspartate aminotransferase level,alkaline phosphatase level,gamma-glutamyl transpeptidase level,or lactate dehydrogenase level(P>0.05).The MCI group was younger than the non-MCI group,and the platelet count and alanine aminotransferase level were higher in the MCI group(P<0.05).Logistic regression analysis showed that platelet count and alanine aminotransferase level were independent risk factors for NAFLD combined with MCI(P<0.05).Conclusion:Platelet count and alanine aminotransferase level are independent risk factors for NAFLD patients with MCI,and targeted clinical interventions should be implemented.

关 键 词：非酒精性脂肪性肝病 轻度认知功能障碍 影响因素 

分 类 号：R575.5[医药卫生—消化系统] R749.25[医药卫生—内科学]