美托洛尔联合人血白蛋白治疗基底节区脑出血的效果观察  

Effect of Metoprolol Combined with Human Serum Albumin in the Treatment of Basal Ganglia Hemorrhage

作　　者：熊江波 曹明川 Xiong Jiangbo;Cao Mingchuan(Department of Neurosurgery,Chongqing Qianjiang Central Hospital,Chongqing 409700,China)

机构地区：[1]重庆市黔江中心医院神经外科,重庆409700

出　　处：《中外医药研究》2025年第4期58-60,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:观察美托洛尔联合人血白蛋白(ALB)治疗基底节区脑出血的效果。方法:选取2024年1—10月于重庆市黔江中心医院接受治疗的62例基底节区脑出血患者为研究对象,随机分为对照组和试验组,各31例。对照组接受常规治疗,试验组在对照组基础上接受酒石酸美托洛尔与ALB治疗。比较两组血肿及脑水肿体积、意识障碍程度、不良反应发生情况。结果:治疗5、10、20、30 d后,两组血肿与脑水肿体积缩小(P<0.05);治疗10、20、30 d后,试验组血肿与脑水肿体积小于对照组(P<0.05)。治疗10、20、30 d后及随访结束,两组格拉斯哥昏迷量表评分升高,美国国立卫生研究院卒中量表评分降低(P<0.05);治疗30 d后及随访结束,试验组格拉斯哥昏迷量表评分高于对照组,美国国立卫生研究院卒中量表评分低于对照组(P<0.05)。试验组肺部感染率低于对照组(P=0.039)。结论:美托洛尔联合ALB治疗基底节区脑出血的效果较好,可促进血肿及脑水肿吸收,改善意识障碍,降低肺部感染风险。Objective:To observe the effect of metoprolol combined with human serum albumin(ALB)in the treatment of basal ganglia hemorrhage.Methods:Sixty-two patients with basal ganglia hemorrhage treated at Chongqing Qianjiang Central Hospital from January to October 2024 were selected as the study subjects and randomly divided into a control group and an experimental group,with 31 patients in each group.The control group received conventional treatment,while the experimental group received metoprolol tartrate and ALB in addition to the conventional treatment.The volume of hematoma and cerebral edema,the degree of consciousness disturbance,and the incidence of adverse reactions were compared between the two groups.Results:After 5,10,20,and 30 days of treatment,the volume of hematoma and cerebral edema in both groups decreased(P<0.05).After 10,20,and 30 days of treatment,the volume of hematoma and cerebral edema in the experimental group was smaller than that in the control group(P<0.05).After 10,20,and 30 days of treatment and at the end of follow-up,the Glasgow Coma Scale scores increased and the National Institutes of Health Stroke Scale scores decreased in both groups(P<0.05).After 30 days of treatment and at the end of follow-up,the Glasgow Coma Scale score of the experimental group was higher than that of the control group,and the National Institutes of Health Stroke Scale score was lower than that of the control group(P<0.05).The pulmonary infection rate in the experimental group was lower than that in the control group(P=0.039).Conclusion:Metoprolol combined with ALB is effective in the treatment of basal ganglia hemorrhage,promoting the absorption of hematoma and cerebral edema,improving consciousness disturbance,and reducing the risk of pulmonary infection.

关 键 词：基底节区脑出血 美托洛尔 人血白蛋白 

分 类 号：R743.34[医药卫生—神经病学与精神病学]