血小板聚集试验在脑梗死治疗中的应用价值探讨  

Application Value of Platelet Aggregation Test in the Treatment of Cerebral Infarction

作　　者：宋磊[1] Song Lei(Yancheng Jianhu County People's Hospital,Yancheng 224700,Jiangsu Province,China)

机构地区：[1]盐城市建湖县人民医院,江苏盐城224700

出　　处：《中外医药研究》2025年第4期64-66,共3页JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH

摘　　要：目的:探讨血小板聚集试验在脑梗死患者治疗中的应用价值。方法:选择2022年2—8月盐城市建湖县人民医院收治的脑梗死患者86例为研究对象,按照随机数字表法分成对照组(n=43)与观察组(n=43)。对照组应用阿司匹林联合氯吡格雷常规方案,观察组治疗前进行血小板聚集试验,根据试验结果确定阿司匹林及氯吡格雷服用剂量。对比两组美国国立卫生院卒中量表(NIHSS)评分、临床疗效、D-二聚体(D-D)水平与血小板聚集率。结果:治疗前,两组NIHSS评分比较,无统计学差异(P>0.05);治疗7、14、30 d,两组NIHSS评分降低,观察组低于对照组(P<0.05)。观察组治疗总有效率高于对照组(P=0.019)。治疗前,两组D-D水平及血小板聚集率比较,无统计学差异(P>0.05);治疗30 d,两组D-D水平、血小板聚集率降低,观察组低于对照组(P<0.05)。结论:脑梗死患者治疗前进行血小板聚集试验,并根据血小板聚集情况确定服用剂量,可提高治疗效果,改善患者神经功能,降低血浆D-D水平与血小板聚集率。Objective:To investigate the application value of platelet aggregation test in the treatment of cerebral infarction patients.Methods:A total of eighty-six patients with cerebral infarction admitted to Yancheng Jianhu County People's Hospital from February to August 2022 were selected as the study objects,and divided into control group(n=43)and observation group(n=43)according to random number table method.The control group was treated with aspirin combined with clopidogrel.Platelet aggregation test was performed in the observation group before treatment,and the dosage of aspirin and clopidogrel was determined according to the test results.National institutes of health stroke scale(NIHSS)score,clinical efficacy,D-dimer(D-D)level and platelet aggregation rate were compared between the two groups.Results:Before treatment,there was no significant difference in NIHSS score between the two groups(P>0.05).After 7,14 and 30 days of treatment,the NIHSS score of both groups was decreased,and the observation group was lower than the control group(P<0.05).The total effective rate of observation group was higher than that of control group(P=0.019).Before treatment,there were no significant differences in D-D level and platelet aggregation rate between the two groups(P>0.05).After 30 days of treatment,the D-D level and platelet aggregation rate of both groups were decreased,and the observation group was lower than the control group(P<0.05).Conclusion:Platelet aggregation test before treatment in cerebral infarction patients,and determine the dosage according to the platelet aggregation,can improve the therapeutic effect,improve the nerve function of patients,and reduce the plasma D-D level and platelet aggregation rate.

关 键 词：脑梗死 血小板聚集试验 阿司匹林 氯吡格雷 

分 类 号：R743.33[医药卫生—神经病学与精神病学]