MALDI-MSI技术用于毛发中毒(药)物分析的研究进展  

Research Progress on the Application of MALDI-MSI in Hair Analysis

作　　者：纪佼佼 王鑫 林佳曼 徐多麒 严慧 沈敏 JI Jiao-jiao;WANG Xin;LIN Jia-man;XU Duo-qi;YAN Hui;SHEN Min(College of Criminal Science and Technology,Criminal Investigation Police University of China,Shenyang 110854,China;Shanghai Key Laboratory of Forensic Medicine,Key Laboratory of Forensic Science,Minis-try of Justice,Shanghai Forensic Service Platform,Academy of Forensic Science,Shanghai 200063,China;School of Criminal Investigation,People’s Public Security University of China,Beijing 100038,China)

机构地区：[1]中国刑事警察学院刑事科学技术学院,辽宁沈阳110854 [2]司法鉴定科学研究院、上海市法医学重点实验室司法部司法鉴定重点实验室、上海市司法鉴定专业技术服务平台,上海200063 [3]中国人民公安大学侦查学院,北京100038

出　　处：《法医学杂志》2024年第6期542-549,共8页Journal of Forensic Medicine

基　　金：国家自然科学基金资助项目(81772022);司法部司法鉴定重点实验室资助项目;上海市法医学重点实验室资助项目(21DZ2270800);上海市司法鉴定专业技术服务平台资助项目。

摘　　要：质谱成像(mass spectrometry imaging,MSI)是一种结合质谱技术和影像可视化技术的新兴高科技“拍照”手段,可以同时监测生物样品中多种分子的空间分布情况。近年来,利用该技术特性对毛发中药物的分布情况进行可视化研究,其中以基质辅助激光解吸电离-质谱成像(matrix-assisted laser desorption ionization-mass spectrometry imaging,MALDI-MSI)技术在毛发分析中的应用最为广泛。本文基于MALDIMSI技术的原理,探讨其应用于毛发分析的关键技术要素,梳理毛发MSI分析的研究成果,认为提高MALDI-MSI技术的电离效率、分辨率、灵敏度和稳定性依旧是未来的探索方向,简化数据分析和建立数据库将有助于推动MALDI-MSI成为毛发中毒(药)物分析的常规分析技术。Mass spectrometry imaging(MSI)is an emerging high-tech“photography”method combining mass spectrometry and image visualization technologies,which can simultaneously monitor the spatial distribution of multiple molecules in biological samples.In recent years,the characteristics of this technology have been used to visually study the distribution of drugs in hair,among which matrix-assisted laser desorption ionization-mass spectrometry imaging(MALDI-MSI)technology has been most widely applied in hair analysis.Based on the principle of MALDI-MSI technology,this paper discusses the key technical elements of MALDI-MSI technology applied to hair analysis and reviews the research achievements of MSI in hair analysis.It concludes that improving the ionization efficiency,resolution,sensitivity and stability of MALDI-MSI technology remains the future exploration direction,and simplifying data analysis and establishing databases will help promote MALDI-MSI as a routine analytical technique for hair analysis.

关 键 词：法医学 毒物分析 基质辅助激光解吸电离-质谱成像 毛发 关键技术 数据处理 可视化 综述 

分 类 号：R89[医药卫生—法医学] DF795.1[医药卫生—临床医学] D919.1[政治法律—诉讼法学]