体内尼秦类新精神活性物质的分析  

In Vivo Analysis of New Psychoactive Substances:Nitazenes

作　　者：高国庆 阳硕 周莉英 杜诗蓓 施妍 GAO Guo-qing;YANG Shuo;ZHOU Li-ying;DU Shi-bei;SHI Yan(Shanghai Key Laboratory of Forensic Medicine,Key Laboratory of Forensic Science,Ministry of Justice,Shanghai Forensic Service Platform,Academy of Forensic Science,Shanghai 200063,China;School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China)

机构地区：[1]司法鉴定科学研究院、上海市法医学重点实验室、司法部司法鉴定重点实验室、上海市司法鉴定专业技术服务平台,上海200063 [2]中国药科大学药学院,江苏南京210009

出　　处：《法医学杂志》2024年第6期597-607,共11页Journal of Forensic Medicine

基　　金：国家重点研发计划资助项目(2022YFC3302003);上海市法医学重点实验室资助项目(21DZ2270800);上海市司法鉴定专业技术服务平台资助项目;上海市科技计划资助项目(24DZ2203000)。

摘　　要：尼秦类新精神活性物质是一类最新流行于非法物质市场的合成阿片类物质,具有效力高、安全范围窄等特点。相比于传统阿片类物质,吸食该类物质后更容易导致严重的呼吸抑制。近年来,尼秦类新精神活性物质滥用事件频发,已在全球范围内造成数百起中毒或死亡案件,严重威胁个体健康和公共安全。随着尼秦类新精神活性物质的不断涌现,对该类物质的鉴识研究受到越来越广泛的关注。本文综述了常见尼秦类新精神活性物质的结构特点、体内药理学表征以及分析方法,以期为该类物质在法医毒物学中的研究提供依据和参考。Nitazenes are a class of synthetic opioids that have recently emerged in the illegal drug market.They are characterized by high potency and a narrow therapeutic window.Compared with traditional opioids,these substances are more likely to cause severe respiratory depression.In recent years,the abuse of nitazenes has occurred frequently,causing hundreds of overdose deaths worldwide,and posing a serious threat to individual health and public safety.As more nitazenes continue to emerge,research on the identification of these substances has received increasing attention.This paper reviews the structural characteristics,in vivo and in vitro pharmacological characterizations and analysis methods of common nitazenes,aiming to provide a basis and reference for the study of these substances in forensic toxicology.

关 键 词：法医学 毒物分析 新精神活性物质 尼秦类 体内 分析方法 综述 

分 类 号：R89[医药卫生—法医学] DF795.1[医药卫生—临床医学] D919.1[政治法律—诉讼法学]