肠缺血/再灌注损伤对远端器官功能的影响  

Effects of intestinal ischemia-reperfusion injury on distal organ function

作　　者：邢雨润 陈苏颖 屠金恒 何伯圣[1] XING Yurun;CHEN Suying;TU Jinheng;HE Bosheng(Department of Imaging,the Second Affiliated Hospital of Nantong University,Nantong 226001;Department of Emergency,Affiliated Hospital of Nantong University,Nantong 226006,China)

机构地区：[1]南通大学第二附属医院影像科,江苏南通226001 [2]南通大学附属医院急诊科,江苏南通226006

出　　处：《基础医学与临床》2025年第3期395-398,共4页Basic and Clinical Medicine

基　　金：江苏省卫生健康委员会重点科研项目(ZD2021059)。

摘　　要：肠缺血/再灌注(I/R)损伤首先对肠道本身造成损伤,肠道屏障和功能受损后,肠道内的细菌、代谢物及内毒素会透过受损的肠黏膜进入门静脉系统,后通过肝脏参与全身微循环系统作用与远端器官。导致进一步损伤并诱发再灌注综合征和多器官功能障碍综合征(MODS),严重时可导致死亡。Intestinal ischemia-reperfusion(I/R)injury firstly causes damage to the intestine itself.After the intestinal barrier and function are impaired,bacteria,metabolites and endotoxins in the intestine will enter the portal system through the damaged intestinal mucosa,and then participate in the systemic microcirculatory system through the liver to act on the distal organs.This leads to further damage and induces reperfusion syndrome and multiple organ dysfunction syndromes(MODS),which can lead to death in severe cases.

关 键 词：缺血/再灌注损伤 多器官功能障碍综合征 NF-ΚB信号通路 远端器官 

分 类 号：R574.5[医药卫生—消化系统]