P2X受体在神经病理性疼痛和偏头痛中的研究进展  

Progress of P2X receptor in neuropathic pain and migraine

作　　者：杨斌[1] 葛朝明[1] YANG Bin;GE Zhaoming(Department of Neurology,the Second Clinical School of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第二临床医学院神经内科,甘肃兰州730000

出　　处：《基础医学与临床》2025年第3期409-412,共4页Basic and Clinical Medicine

摘　　要：偏头痛是一种病因不明的复杂神经系统疾病,涉及遗传和环境因素,偏头痛的发病机制与小胶质细胞的激活及炎性因子密切相关。ATP是P2X受体(P2XR)的配体,P2XR是一种在神经元和神经胶质细胞中广泛表达的配体门控离子通道(LGIC)。本篇综述阐述了P2X(P2X3、P2X4、P2X7)受体通过不同机制调节小胶质细胞的激活和释放炎性因子介导神经病理性疼痛和偏头痛的发生,这将成为偏头痛治疗的潜在靶点。Migraine is a complex neurological disorder with unknown etiology,involving genetic and environmental factors.The pathogenesis of migraine is closely related to the activation of microglia and inflammatory factors.ATP is a ligand for the P2X receptor(P2XR),a ligand gated ion channel(LGIC)widely expressed in neurons and glial cells.This review elucidates that P2X(P2X3,P2X4,P2X7)receptors regulate the activation of microglia and release of inflammatory factors through different signaling pathways,mediating neuropathic pain and migraine occurrence,providing potential targets for the treatment of migraine.

关 键 词：偏头痛 P2X受体 三磷酸腺苷(ATP) 神经病理性疼痛 

分 类 号：R74[医药卫生—神经病学与精神病学]