阿尔茨海默病的血浆生物标志物研究进展  

Recent advance in plasma biomarkers for Alzheimer's disease

作　　者：周芷馨 徐运[2] Zhou Zhixin;Xu Yun(Drum Tower School of Clinical Medicine,Nanjing Medical University,Nanjing 210008,China;Department of Neurology,Drum Tower Hospital Affiliated to Clinical College of Nanjing Medical University,Nanjing 210008,China)

机构地区：[1]南京医科大学鼓楼临床医学院,南京210008 [2]南京大学医学院附属鼓楼医院神经内科,南京210008

出　　处：《中华神经医学杂志》2025年第2期187-192,共6页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(82130036);科技创新2030-"脑科学与类脑研究"重大项目(2022ZD0211800);江苏省科技厅医学重点项目(BE2020620);"十四五"江苏省医学重点学科(ZDXKA202216)。

摘　　要：阿尔茨海默病(AD)是老年人中最常见的神经退行性疾病,目前缺乏早期诊断方法和干预手段。近年来,血浆生物标志物在AD的诊断研究中取得了重大进展。本文对AD血浆生物标志物的种类、检测影响因素及其在AD早期诊断、预后评估、疾病进展监测中的潜力进行综述,以期为开发更准确、便捷的AD早期诊断方法提供参考。Alzheimer's disease(AD)stands as the most common neurodegenerative disorder among the elderly.Currently,there is a lack of effective methods for early diagnosis and intervention.In recent years,significant progress has been made in the study of plasma biomarkers in AD diagnosis.This article reviews the various types of AD plasma biomarkers and their influencing factors for detection,and their potential applications in early diagnosis,prognosis,and monitoring of AD,so as to develop a more accurate and convenient diagnostic method for AD.

关 键 词：阿尔茨海默病 血浆生物标志物 TAU蛋白 早期诊断 

分 类 号：R73[医药卫生—肿瘤]