无创脑刺激在阿尔茨海默病中的研究进展  

Recent advance in role of non-invasive brain stimulation in Alzheimer's disease

作　　者：王爰凯 兰宇飞 郝飞云朵 张曼卿 李磊 左博明 李扬 谢欣耘 郭洪波[1] Wang Yuankai;Lan Yufei;Hao Feiyunduo;Zhang Manqing;Li Lei;Zuo Boming;Li Yang;Xie Xinyun;Guo Hongbo(National Key Clinical Specialty,Engineering Technology Research Center on Diagnosis and Treatment of Cerebrovascular Diseases in Ministry of Education,Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration,Neurosurgery Center,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China;Department of Geriatrics,Zhujiang Hospital,Southern Medical University,Guangzhou 510282,China)

机构地区：[1]南方医科大学珠江医院神经外科中心,国家临床重点专科,脑血管病诊断与治疗教育部工程研究中心,广东省普通高校脑功能修复与再生重点实验室,广州510282 [2]南方医科大学珠江医院老年病科,广州510282

出　　处：《中华神经医学杂志》2025年第2期193-200,共8页Chinese Journal of Neuromedicine

基　　金：吴阶平医学基金会科研专项资助基金(320.6750.2024-03-37)。

摘　　要：阿尔茨海默病(AD)是一种进行性加重的神经退行性疾病,也是导致老年人痴呆的主要原因。近年来,无创脑刺激(NIBS)如经颅磁刺激、经颅电刺激、聚焦超声和经颅光生物调节被广泛用于AD患者的治疗。目前NIBS虽然能够改善AD患者的临床症状,但是其疗效尚存在一定争议。本文现围绕近年来NIBS治疗AD的最新研究进展进行综述,以期为临床工作者提供参考。Alzheimer's disease(AD)is a kind of progressive neurodegenerative disease,which has become the leading cause of dementia in the elderly.In recent years,non-invasive brain stimulation(NIBS),including transcranial magnetic stimulation,transcranial electrical stimulation,focused ultrasound stimulation and transcranial photobiomodulation,has been widely used in AD treatment.Although NIBS can improve the clinical symptoms of AD patients,its efficacy is still controversial.This article reviews the latest research progress in role of NIBS in AD so as to provide reference for clinical workers.

关 键 词：阿尔茨海默病 无创脑刺激 经颅磁刺激 经颅电刺激 聚焦超声 经颅光生物调节 

分 类 号：R74[医药卫生—神经病学与精神病学]