NRG-1/ErbB信号通路对周围神经肌肉系统的调控作用  

Regulatory effect of NRG-1/ErbB signaling pathway on peripheral neuromuscular system

作　　者：马铭 王艳[2] 赵明月 吴珊红 Ma Ming;Wang Yan;Zhao Mingyue;Wu Shanhong(Graduate School,Heilongjiang University of Traditional Chinese Medicine,Harbin 150040,China;Department of Rehabilitation Centre,Second Hospital of Heilongjiang University of Traditional Chinese Medicine,Harbin 150001,China)

机构地区：[1]黑龙江中医药大学研究生院,哈尔滨150040 [2]黑龙江中医药大学附属第二医院康复中心,哈尔滨150001

出　　处：《中华神经医学杂志》2025年第2期207-212,共6页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金面上项目(82274623)。

摘　　要：周围神经损伤后神经再生缓慢,骨骼肌由于长期得不到神经的支配、缺乏营养物质和神经电活动刺激而逐渐产生肌萎缩。神经调节蛋白-1(NRG-1)与表皮生长因子受体(ErbB)结合可激活多个细胞内复杂的信号网络,对神经和肌肉产生影响。本文围绕NRG-1/ErbB信号通路对周围神经、肌肉及神经肌肉接头(NMJ)的调控作用进行综述,以期为失神经后肌萎缩寻找新的治疗靶点提供参考。After peripheral nerve injury,nerve regeneration is slow,and skeletal muscles gradually atrophy due to long-term lack of nerve innervation,nutrient deficiency,and lack of stimulation of nerve electrical stimulation.Neuregulin-1(NRG-1)and epidermal growth factor receptor(ErbB)can activate multiple complex intracellular signaling networks to affect the nerves and muscles.This article reviews the regulatory effect of NRG-1/ErbB signaling pathway on peripheral nerves,muscles,and neuromuscular junctions,aiming to provide references for finding new therapeutic target for denervated muscle atrophy.

关 键 词：失神经后肌萎缩 NRG-1/ErbB信号通路 施万细胞 乙酰胆碱受体 

分 类 号：R745[医药卫生—神经病学与精神病学]