单相和双相抑郁患者睁眼和闭眼静息态脑电功率谱分析  

Analysis of electroencephalogram power spectrum in patients with unipolar and bipolar depression under eyes-open and eyes-closed resting states

作　　者：黄友俊 何心雨 黄成尧 于泽安 侯晓菲 张果儿 王睿智 王优 Huang Youjun;He Xinyu;Huang Chengyao;Yu Ze'an;Hou Xiaofei;Zhang Guo'er;Wang Ruizhi;Wang You(Department of Psychology,School of Public Health,Southern Medical University,Guangzhou 510515,China;Department of Psychiatry,Zhujiang Hospital,Southern Medical University,Guangzhou 510280,China)

机构地区：[1]南方医科大学公共卫生学院心理学系,广州510515 [2]南方医科大学珠江医院精神心理科,广州510280

出　　处：《中华行为医学与脑科学杂志》2025年第1期24-29,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：教育部人文社会科学研究青年基金(22YJCZH182);广东大学生科技创新培育专项资金(pdjh2023b0113)。

摘　　要：目的分析单相和双相抑郁患者在睁眼和闭眼两种静息状态下的全脑平均相对脑电功率谱特征。方法2022年8月至2023年12月,纳入单相抑郁患者38例(UD组)、双相抑郁患者48例(BD组)和健康对照43例(HC组),记录64导脑电图,睁眼(EO)静息状态和闭眼(EC)静息状态交替两次。采用SPSS 25.0软件进行t检验、单因素方差分析、Mann-WhitneyU检验和Kruskal-WallisH检验。结果UD、BD与HC组在睁眼闭眼状态的delta波和beta波全脑平均相对功率均差异无统计学意义(均P>0.05)。3组在睁眼闭眼状态的theta波全脑平均相对功率均差异有统计学意义(H=7.852~12.583,均P<0.05)。进一步两两比较,在第一次睁眼和闭眼阶段,UD组和BD组的theta波全脑平均相对功率均高于HC组[EO1:0.18(0.17,0.21),0.19(0.16,0.21),0.16(0.14,0.18);EC1:0.15(0.13,0.21),0.15(0.13,0.20),0.13(0.10,0.16);均P<0.05];在第二次睁眼和闭眼阶段,BD组的theta波全脑平均相对功率均高于HC组[EO2:0.18(0.15,0.22),0.16(0.14,0.18);EC2:0.15(0.13,0.19),0.13(0.11,0.16);均P<0.05]。3组在第一次睁眼和闭眼阶段以及第二次闭眼阶段的alpha波全脑平均相对功率均差异有统计学意义(H=5.027~10.668,均P<0.05)。进一步两两比较发现,在第一次睁眼阶段,BD组的alpha波全脑平均相对功率高于UD组[0.20(0.16,0.25,0.14(0.11,0.22),P=0.003],在随后的闭眼阶段,UD组的alpha波全脑平均相对功率低于HC组[EC1:0.40(0.33,0.46),0.51(0.40,0.58);EC2:0.41(0.35,0.50),0.48(0.43,0.58);均P<0.05]。结论在静息状态初始阶段,单相和双相抑郁患者睁眼和闭眼theta波活动均存在异常,且两类患者之间睁眼alpha波活动不同,这可能为临床上鉴别单相和双相抑郁患者提供客观辅助依据。ObjectiveTo analyze the electroencephalogram(EEG)average relative power spectrum in patients with unipolar and bipolar depression under the eyes-open and eyes-closed resting states.MethodsA total of 38 patients with unipolar depression(UD group),48 patients with bipolar depression(BD group),and 43 healthy controls(HC group)were recruited from August 2022 to December 2023.The 64-channel EEG was recorded under eyes-open(EO)and eyes-closed(EC)resting states which alternated twice.The Mann-Whitney U test and Kruskal-Wallis H test were performed by SPSS 25.0 software.ResultsThere were no significant differences in the average relative power of delta and beta bands among the UD,BD and HC groups in all EO and EC states(all P>0.05).The average relative power of theta band in the three groups showed statistically significant differences in all EO and EC states(H=7.852-12.583,all P<0.05).Further pairwise comparisons showed that in the first EO and EC stage,the average relative power of theta band of the UD and BD groups were significantly higher than that of the HC group(EO1:0.18(0.17,0.21),0.19(0.16,0.21),0.16(0.14,0.18),EC1:0.15(0.13,0.21),0.15(0.13,0.20),0.13(0.10,0.16);all P<0.05).In the second EO and EC stage,the average relative power of theta band of the BD group was significantly higher than that of the HC group(EO2:0.18(0.15,0.22),0.16(0.14,0.18),EC2:0.15(0.13,0.19),0.13(0.11,0.16);both P<0.05).There were statistically significant differences in the average relative power of alpha band among the three groups in the first EO and EC stage,as well as the second EC stage(H=5.027-10.668,all P<0.05).Further pairwise comparisons showed that in the first EO stage,the average relative power of alpha band in the BD group was significantly higher than that in the UD group(0.20(0.16,0.25),0.14(0.11,0.22),P=0.003),and in the following EC stages,the average relative power of alpha band in the UD group was significantly lower than that in the HC group(EC1:0.40(0.33,0.46),0.51(0.40,0.58),EC2:0.41(0.35,0.50),0.48(0.43,0.58);both P

关 键 词：单相抑郁 双相抑郁 静息态 睁眼 闭眼 脑电 功率谱 

分 类 号：R749.4[医药卫生—神经病学与精神病学]