选择性脊神经后根切断术联合生物反馈综合治疗痉挛性脑瘫患儿的临床效果  

Clinical Efficacy of Selective Posterior Rhizotomy of Spinal Nerve Combined with Biofeedback Comprehensive Treatment for Children with Spastic Cerebral Palsy

作　　者：张振武 陈业涛[2] 吴月奎 许琦 ZHANG Zhenwu;CHEN Yetao;WU Yuekui;XU Qi

机构地区：[1]厦门大学第一附属医院翔安院区(厦门市第五医院),福建厦门361000 [2]清华大学玉泉医院

出　　处：《中外医学研究》2025年第5期144-147,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究选择性脊神经后根切断术联合生物反馈综合治疗痉挛性脑瘫患儿的临床效果。方法:选取2021年2月—2024年2月厦门大学附属第一医院翔安院区和清华大学玉泉医院接收的101例痉挛性脑瘫患儿。采用随机数表法分为对照组和观察组。对照组(55例)采用选择性脊神经后根切断术治疗,观察组(46例)联合生物反馈综合治疗。对比两组的肌张力情况、运动功能、血清指标及并发症情况。结果:治疗前,两组改良Ashworth痉挛评定量表(MAS)评分、粗大运动功能评估量表(CMFM-88)评分、精细运动功能评估量表(FMFM)评分、血清指标比较,差异均无统计学意义(P>0.05);治疗后,观察组MAS评分较对照组低,CMFM-88评分、FMFM评分较对照组高,差异有统计学意义(P<0.05);治疗后,观察组血清神经生长因子(NGF)水平高于对照组,内皮素(ET)低于对照组,差异有统计学意义(P<0.05)。两组并发症总发生率比较,差异无统计学意义(P>0.05)。结论:选择性脊神经后根切断术联合生物反馈综合治疗痉挛性脑瘫患儿的效果较好,对改善患儿的肌张力、运动功能具有积极意义,有利于改善整体预后,且治疗方式安全、可靠。Objective:To evaluate the clinical efficacy of selective posterior rhizotomy of spinal nerve combined with biofeedback comprehensive therapy in children with spastic cerebral palsy.Method:A total of 101 children with spastic cerebral palsy who were admitted to Xiang’an Branch,the First Affiliated Hospital of Xiamen University and Tsinghua University Yuquan Hospital from February 2021 to February 2024 were selected.They were randomly divided into two groups by random number table method.The control group(55 cases)treated with selective posterior rhizotomy of spinal nerve,and the observation group(46 cases)treated combined with biofeedback comprehensive therapy.The muscle tone,motor function,serum indicators,and complications between the two groups were compared.Result:Before treatment,there were no statistically significant differences in the scores of the modified Ashworth spasm assessment scale(MAS),coarse motor function assessment scale(CMFM-88),fine motor function assessment scale(FMFM),and serum indicators between the two groups(P>0.05).After treatment,compared to the control group,the observation group had lower MAS,higher CMFM-88 score and FMFM score,and the differences were statistically significant(P<0.05).After treatment,the serum levels of nerve growth factor(NGF)and endothelin(ET)in the observation group were higher,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion:Selective posterior rhizotomy of spinal nerve combined with biofeedback comprehensive therapy is effective for children with spastic cerebral palsy,which has positive significance for improving muscle tension and motor function of children,and is conducive to improving the overall prognosis,and the treatment is safe and reliable.

关 键 词：选择性脊神经后根切断术 生物反馈综合治疗 痉挛性脑瘫 临床疗效 肌张力 

分 类 号：R742.3[医药卫生—神经病学与精神病学]