基于学科交叉融合及创新能力培养的实验教学——姜黄素衍生物合成及物理常数测定  

Experiment Teaching Based on Interdisciplinary Integration and Innovative Ability Cultivation:Synthesis of Curcumin Derivatives and Determination of Their Physical Constants

作　　者：王涛[1] 朱丽萍 罗翔 龚晶 曾丽云[1] WANG Tao;ZHU Li-Ping;LUO Xiang;GONG Jing;ZENG Li-Yun(School of Pharmaceutical Sciences,Guangzhou University of Chinese Medicine,Guangzhou 510006,China)

机构地区：[1]广州中医药大学中药学院,广东广州510006

出　　处：《化学教育(中英文)》2025年第4期85-94,共10页Chinese Journal of Chemical Education

基　　金：广州中医药大学“双一流”与高水平大学建设项目(2021xk87,[2022]97号)。

摘　　要：基于学科交叉融合和人才培养目标开设体现药学专业特色的科研训练实验:姜黄素衍生物合成及物理常数测定。本项目针对中药有效成分姜黄素结构的缺陷,着重采用Knoevenagel、Knorr缩合对其β-二酮及活泼亚甲基进行合理的结构修饰,产物经结构确证后,进一步开展相关物理常数的测定,初步探讨修饰位点、取代基等与理化性质间的关联。整个实验将有机合成中的实验技能与仪器分析手段进行了有效融合,是化学学科不同分支实验整合的探索与创新。通过项目引导方式对实验开展综合升级,使学生在项目的探究中不断提升科学素养和创新能力。The research training experiment“synthesis of curcumin derivatives and determination of their physical constants”,which is reflect the characteristics of pharmacy,had been offered based on interdisciplinary integration and talent cultivation objectives.This project was performed aiming at the defects in the structure of curcumin.Reasonable structural modification was carried out via Knoevenagel and Knorr condensation atβ-diketones and active methylene group of curcumin.After the structures of the target product were confirmed,further determination of related physical constants was carried out.The correlation between modification sites,substituents,and physicochemical properties was preliminary explored.The experiment incorporates organic synthesis skills and instrumental analysis methods,which is an exploration and innovation of experiment for integrating different branches of chemistry.Comprehensive upgrading of experimental course was conducted through program guidance.It was helpful for improving scientific literacy and innovation ability of undergraduate students in the exploration of the program.

关 键 词：有机化学实验 学科交叉融合 KNOEVENAGEL缩合 Knorr缩合 

分 类 号：G642.423[文化科学—高等教育学] O629-4[文化科学—教育学]