2009-2019年江苏省肿瘤登记地区白血病发病趋势及年龄变化特征分析  

Trends of Incidence and Age at Onset of Leukemia in Jiangsu Cancer Registration Areas from 2009 to 2019

作　　者：卢海燕[1] 董鑫鑫 朱星星[1] 张德坤[1] 杨玉雪 赵小兰[1] 韩仁强[2] 周金意[2] 陶然[2] 缪伟刚 罗鹏飞[2] LU Haiyan;DONG Xinxin;ZHU Xingxing;ZHANG Dekun;YANG Yuxue;ZHAO Xiaolan;HAN Renqiang;ZHOU Jinyi;TAO Ran;MIAO Weigang;LUO Pengfei(Taizhou Municipal Center for Disease Control and Prevention,Taizhou 225300,China;Jiangsu Provincial Center for Disease Control and Prevention,Nanjing 210009,China)

机构地区：[1]泰州市疾病预防控制中心,江苏泰州225300 [2]江苏省疾病预防控制中心,江苏南京210009

出　　处：《中国肿瘤》2025年第2期125-131,共7页China Cancer

摘　　要：[目的]分析2009-2019年江苏省肿瘤登记地区白血病发病趋势及年龄变化情况。[方法]选取江苏省2009-2019年连续登记的肿瘤监测数据,进行审核、整理,最终共纳入16个登记处的监测数据,提取数据库中全部白血病患者的发病信息,计算白血病发病率、中国人口标化发病率(中标率)、平均年度变化百分比(average annual percentage change,AAPC)、标化平均发病年龄等,了解发病年龄结构改变及出生队列变化情况。[结果] 2009-2019年江苏省肿瘤登记地区白血病发病率从5.22/10万上升至7.88/10万,上升趋势具有统计学意义(AAPC=4.95%,95%CI:3.82%~6.09%),标化后仍呈上升趋势(AAPC=2.97%,95%CI:1.52%~4.43%),按性别和地区分层后上升趋势仍存在。各年龄别发病率均呈上升趋势,且在年龄相同但出生年份不同的人群中,发病率随出生年份的增加而上升。人群呈现发病年龄构成后移的趋势,60岁以上人群构成随年份增加。2009年江苏省白血病的平均发病年龄为48.62岁,2019年为57.96岁,平均发病年龄后移(β=0.773,P<0.001),标化后只有农村地区的平均发病年龄随年份的增加而上升(β=0.428,P=0.017)。[结论] 2009-2019年江苏省肿瘤登记地区白血病发病率呈上升趋势,发病年龄后移,亟需加强白血病的早期筛查和防治工作。[Purpose]To analyze the trends of incidence and age at onset of leukemia in Jiangsu cancer registration areas from 2009 to 2019.[Methods]The continuous monitoring data of leukemia from 2009 to 2019 were collected from 16 cancer registries in Jiangsu Province.All datasets were checked and evaluated based on data quality control criteria and were included in the analysis.Crude incidence rate(CIR),age-standardized incidence rate by Chinese standard population(ASIRC),the average annual percentage change(AAPC),the standardized average age at onset,the changes in the age structure of incidence and the changes in the birth cohort by year were calculated.[Results]The incidence rate of leukemia significantly increased from 5.22/105 in 2009 to 7.88/105 in 2019,with a significant upward trend(for CIR,AAPC=4.95%,95%CI:3.82%~6.09%;for ASIRC,AAPC=2.97%,95%CI:1.52%~4.43%).The incidence rates were increased in all age groups and increased with the birth cohort by years.There was a tendency of backward shift for the age composition of the population,with the increasing of composition for those over 60 years old.The mean age at onset increased from 48.62 years old in 2009 to 57.96 years old in 2019,with a backward shift in the mean age(β=0.773,P<0.001),and the mean age at onset increased with the year only in rural areas after standardization(β=0.428,P=0.017).[Conclusion]Leukemia incidence rate in Jiangsu Province increased from 2009 to 2019,and the age at onset has shifted backwards.It’s important to strengthen the early prevention and control of leukemia.

关 键 词：白血病 发病率 趋势分析 江苏 

分 类 号：R73-31[医药卫生—肿瘤] R733.7[医药卫生—临床医学]