前列腺素E受体在肿瘤微环境中的作用及其在肿瘤治疗应用中的研究进展  

Roles of Prostaglandin E Receptor in Tumor Microenvironment and Its Potential Application in Cancer Therapy

作　　者：武晓雨 邓炯 王彤 WU Xiaoyu;DENG Jiong;WANG Tong(School of Basic Medical Sciences,Shandong Second Medical University,Weifang 261053,China;Affiliated Hospital of Binzhou Medical College,Binzhou 256603,China)

机构地区：[1]山东第二医科大学基础医学院,山东潍坊261053 [2]滨州医学院附属医院,山东滨州256603

出　　处：《中国肿瘤》2025年第2期159-164,共6页China Cancer

基　　金：国家自然科学基金(82103571);山东省青年自然科学基金(ZR2021QH295);山东省高等学校青年创新团队发展计划(2023KJ249);山东第二医科大学公派国内访学项目(20237-18)。

摘　　要：前列腺素E2(prostaglandin E2,PGE2)对肿瘤微环境(tumor microenvironment,TME)中多种细胞有调控作用,在肿瘤生长、转移、免疫和治疗中起着重要作用。PGE2通过其关键受体--前列腺素E受体(prostaglandin E receptor,EP4)激活下游不同信号通路,调控炎症、免疫细胞的作用和血管生成等促进或抑制肿瘤的发展。EP4作为新兴的抗肿瘤靶点,在化疗辅助和免疫治疗中显示出潜在重要性。然而,EP4的确切调控机制和安全性等问题仍需进一步研究。未来研究方向包括探索EP4在肿瘤微环境中的作用机制,开发更安全有效的EP4药物,并探索其在个体化免疫治疗中的应用前景。Prostaglandin E2(PGE2)regulates a variety of cells in tumor microenvironment(TME)and plays an important role in tumor growth,metastasis and immunity.PGE2 activates different downstream signaling pathways through its key receptor prostaglandin E receptor(EP4),regulating inflammation,immune cell function and angiogenesis to promote or inhibit tumor development.EP4 shows potential application values in adjuvant chemotherapy and immunotherapy as an emerging anti-tumor target.However,future studies on the roles of EP4 in tumor microenvironment,develo-pment of safer and more effective EP4 drugs,and its application in personalized immunotherapy are needed.

关 键 词：前列腺素E受体 前列腺素E2 肿瘤微环境 肿瘤治疗 

分 类 号：R73[医药卫生—肿瘤]