饮用富含多酚的绿茶能否降低泌尿系统肿瘤风险——双样本孟德尔随机化研究  

A two-sample Mendelian randomization study on whether consumption of green tea rich in polyphenols can reduce the risk of urological tumors

作　　者：吴冠伟 严海峰 王家伟[1] 刘和谦 高泽宏 高行宇 陶凌松 Wu Guanwei;Yan Haifeng;Wang Jiawei;Liu Heqian;Gao Zehong;Gao Xingyu;Tao Lingsong(Department of Urology,Affiliated Wuhu Hospital of East China Normal University,Wuhu,Anhui 241000,China)

机构地区：[1]华东师范大学附属芜湖医院泌尿外科,安徽芜湖241000

出　　处：《中国药物与临床》2025年第4期227-233,I0004,共8页Chinese Remedies & Clinics

基　　金：安徽省卫生健康科研项目(AHWJ2022b100);安徽省高校科学研究重点项目(2022AH051520);安徽省芜湖市科技局重点项目(2023jc32)。

摘　　要：目的既往研究显示饮用绿茶可降低泌尿系统肿瘤的发生风险,但这种关联可能是由混杂因素所造成。本研究采用双样本孟德尔随机化(TSMR)方法评估绿茶摄入对泌尿系统肿瘤风险的因果效应。方法从欧洲人群的全基因组关联研究(GWAS)中选择与暴露因素绿茶摄入相关的单核苷酸多态性(SNPs)作为遗传工具变量。作为结局的泌尿系统肿瘤从芬兰数据库(FinnGen)中提取,包括肾癌、肾盂癌、膀胱癌、前列腺癌、阴茎癌和睾丸癌。数据分析主要采用随机效应逆方差加权法(IVW),并采用MR-Egger回归和加权中位数法(WM)和Weighted mode法补充分析;通过Cochran′s Q检验、MR-PRESSO及Leave-one-out法进行敏感性分析。结果本研究共筛选出21个与绿茶摄入的SNPs作为工具变量,IVW结果显示绿茶摄入与泌尿系统肿瘤的发生不存在因果效应[肾癌:OR=0.993,95%CI(0.977,1.010),P=0.442;肾盂癌:OR=0.980,95%CI(0.896,1.072),P=0.663;膀胱癌:OR=0.992,95%CI(0.973,1.011),P=0.382;前列腺癌:OR=1.000,95%CI(0.992,1.007),P=0.910;阴茎癌:OR=0.994,95%CI(0.906,1.091),P=0.903;睾丸癌:OR=1.001,95%CI(0.962,1.041),P=0.969]。研究结果无异质性及水平多效性,敏感性分析验证了结果的可靠性。结论孟德尔随机化分析结果显示绿茶摄入与泌尿系统肿瘤的发生风险可能无明显的因果效应。Objective Previous studies have shown that green tea can reduce the risk of urinary system tumors,but those associations may be caused by confounding factors.To evaluate the causal effect of green tea intake on the risk of urinary system tumors,the two-sample Mendelian randomization(TSMR)approach was used in this study.Methods Single nucleotide polymorphisms(SNPs)associated with green tea intake were selected as genetic instruments from genome-wide association studies(GWAS)of European populations.Associations between genetic variants and urogenital tumors were extracted from the FinnGen database(FinnGen),including kidney cancer,renal pelvis cancer,bladder cancer,prostate cancer,penile cancer,and testis cancer.The data analysis was primarily conducted using the inverse-variance weighted(IVW)method,complemented by MR-Egger regression,the weighted median(WM)method,and the Weighted mode method.Sensitivity analyses were performed using Cochran′s Q test,MR-PRESSO,and the Leave-one-out analysis.Results A total of 21 SNPs associated with green tea intake were identified as instrumental variables.The IVW results showed that there was no causal effect between green tea intake and the occurrence of urinary system tumors(kidney cancer:OR=0.993,95%CI(0.977,1.010),P=0.442;renal pelvis cancer:OR=0.980,95%CI(0.896,1.072),P=0.66;bladder cancer:OR=0.992,95%CI(0.973,1.011),P=0.382;prostate cancer:OR=1.000,95%CI(0.992,1.007),P=0.910;penile cancer:OR=0.994,95%CI(0.906,1.091),P=0.903;testicular cancer:OR=1.001,95%CI(0.962,1.041),P=0.969).The results showed no significant heterogeneity or horizontal pleiotropy,and sensitivity analyses confirmed the reliability of the results.Conclusion The results of Mendelian randomization analysis showed that there was no significant causal effect between green tea intake and the risk of urogenital tumors in European populations.

关 键 词：茶多酚 麦没食子儿茶素没食子酸酯 泌尿系肿瘤 前列腺肿瘤 孟德尔随机化分析 

分 类 号：R737.1[医药卫生—肿瘤]