基于功能性近红外光谱分析技术探究丁螺环酮联合氨磺必利治疗精神分裂症对认知功能的影响  

Effects of buspirone combined with amisulpride on cognitive function in patients with schizophrenia based on functional near-infrared spectroscopy

作　　者：于悦 李超 王锡武 Yu Yue;Li Chao;Wang Xiwu(Department of General Psychiatric,Seventh People′s Hospital of Wenzhou,Wenzhou,Zhejiang325000,China;Department of Behavioral Medicine,Seventh People′s Hospital of Wenzhou,Wenzhou,Zhejiang325000,China)

机构地区：[1]温州市第七人民医院普通精神科,浙江温州325000 [2]温州市第七人民医院行为医学科,浙江温州325000

出　　处：《中国药物与临床》2025年第4期234-239,共6页Chinese Remedies & Clinics

基　　金：浙江省温州市科研项目(Y20210767)。

摘　　要：目的基于功能性近红外光谱(fNIRS)分析技术探究丁螺环酮联合氨磺必利治疗精神分裂症患者的效果及对患者认知功能的影响。方法选取浙江省温州市第七人民医院2022年1月至2024年1月收治的符合研究要求的80例精神分裂症患者,采用随机数字表法分为单一组(应用氨磺必利治疗,40例)和联合组(在单一组的基础上加用丁螺环酮,40例)。比较2组认知功能[蒙特利尔认知评估量表(MoCA)]、fNIRS检测结果[氧合红蛋白浓度(Oxy-Hb)、脱氧血红蛋白(Deoxy-Hb)、总血红蛋白(Total-Hb)治疗前后变化值]、临床症状[阳性与阴性症状量表(PANSS)评分]、生活质量[健康状况调查量表(SF-36)]和不良反应,用Pearson相关系数分析fNIRS检测结果与治疗后的认知功能评分的相关关系。结果治疗后,2组的MoCA评分均升高,且联合组高于单一组(P<0.05);联合组Oxy-Hb、Total-Hb浓度相对变化值均高于单一组(P<0.05),Deoxy-Hb浓度相对变化值低于单一组(P<0.05);Oxy-Hb、Total-Hb浓度相对变化值与治疗后的认知功能评分呈正相关(P<0.05),Deoxy-Hb浓度相对变化值与治疗后的认知功能评分呈负相关(P<0.05);治疗后,2组的PANSS各项评分与总分均降低,且联合组阴性症状评分、一般精神病理症状评分低于单一组(P<0.05),但2组阳性症状评分比较差异无统计学意义(P>0.05),SF-36评分均升高,且联合组高于单一组(P<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论丁螺环酮联合氨磺必利治疗精神分裂症患者可以有效提高患者的认知功能,通过fNIRS检测可以评估患者治疗前后的认知功能,同时联合用药还可以减轻患者的临床症状,提升生活质量,且不会加重不良反应,值得临床推广应用。Objective To explore the effect of buspirone combined with amisulpride in the treatment of patients with schizophrenia based on functional near-infrared spectroscopy(fNIRS)analysis and its influence on cognitive function.Methods A total of 80 patients with schizophrenia who met the research requirements in the hospital from January 2022 to January 2024 were selected and divided into a single group(amisulpride,40)and a combined group(buspirone on the basis of single group,40)by random number table method.The cognitive function[Montreal Cognitive Assessment Scale(MoCA)],fNIRS test results[changes of oxyhemoglobin concentration(Oxy-Hb),deoxyhemoglobin(Deoxy-Hb)and total hemoglobin(Total-Hb)before and after treatment],clinical symptoms[positive and negative symptom scale(PANSS)score],quality of life[36-item short-form health status survey scale(SF-36)]and adverse reactions were compared between the two groups.Pearson correlation coefficient was used to analyze the correlation between fNIRS test results and cognitive function score.Results After treatment,the MoCA score of both groups was increased,and the combined group was higher than the single group(P<0.05).The relative changes of Oxy-Hb and Total-Hb concentrations in combined group were significantly higher than those in single group(P<0.05),while the relative change of Deoxy-Hb concentration was significantly lower than that in single group(P<0.05).The relative changes of Oxy-Hb and Total-Hb concentrations were positively correlated with cognitive function score after the treatment(P<0.05),and the relative change of Deoxy-Hb concentration was negatively correlated with cognitive function score after the treatment(P<0.05).After treatment,the PANSS scores and total scores in the two groups decreased,and the negative symptom scores and general psychopathology symptom scores in the combined group were lower than those of the single group(P<0.05),but there was no significant difference between the two groups′positive symptom scores(P>0.05),and the SF-36 score was i

关 键 词：谱学 近红外线 丁螺环酮 氨磺必利 精神分裂症 认知 

分 类 号：R749.3[医药卫生—神经病学与精神病学]