Impact of microbiota on female fertility and gynecological problems  

作　　者：Manish Kumar Luhan Jiang Hoi-Lam Lai Cheuk-Lun Lee Ernest H.Y.Ng William S.B.Yeung Kai-Fai Lee 

机构地区：[1]Department of Obstetrics and Gynaecology,LKS Faculty of Medicine,The University of Hong Kong,Hong Kong SAR 999077,China [2]Shenzhen Key Laboratory of Fertility Regulation.The University of Hong Kong-Shenzhen Hospital,Shenzhen 518053,China.

出　　处：《Reproductive and Developmental Medicine》2024年第4期242-251,共10页生殖与发育医学(英文版)

基　　金：supported by grants from the Sanming Project of Medicine in Shenzhen,China(SZSM201612083 to W.S.B.Y.),Shenzhen Key Medical Discipline(SZXK2020089),Health and Medical Research Fund,Hong Kong(06173976 to K.F.L.),and Internal research funding from the Department of Obstetrics and Gynaecology,the University of Hong Kong.

摘　　要：The uterus was previously considered a sterile environment for embryo implantation and fetal growth;however,evidence showed that different microorganisms in the female reproductive tract may regulate human fertility.TheLactobacillus family is among the most prevalent bacteria in the vagina and uterus of the female reproductive system.Interestingly,aLactobacillus-dominated(LD)uterine environment is associated with better pregnancy outcomes.Nevertheless,the mechanism by which an LD environment improves pregnancy outcomes is unknown.In the uterus,many commensal bacteria(eg,Bifidobacterium,Prevotella,Enterobacter,Streptococcus,andStaphylococcus)produce short-chain fatty acids(SCFAs),including acetate,butyrate,and propionate.SCFAs are crucial in modulating cytokine production(eg,IL-6 and IL-10)and immune cell populations(eg,T cells and macrophages)during embryo implantation and gynecological diseases.This minireview provides an overview of the roles of lactobacilli and SCFAs in female fertility and related diseases.

关 键 词：Endometrial receptivity Embryo implantation LACTOBACILLUS Short-chain fatty acids INFERTILITY Gynecological diseases 

分 类 号：R71[医药卫生—妇产科学]