细胞膜纳米囊泡用于肿瘤疫苗的研究进展  

Research advances on cellular membrane nanovesicles for tumor vaccines

作　　者：赵佳凝 马婷婷 况小勤 郝茗羽 李春佳雨 涂家生[1,2,3] 孙春萌 吴彦萍[1,4] 陈芊 ZHAO Jianing;MA Tingting;KUANG Xiaoqin;HAO Mingyu;LI Chunjiayu;TU Jiasheng;SUN Chunmeng;WU Yanping;CHEN Qian(State Key Laboratory of Natural Medicines,China Pharmaceutical University,Nanjing 211198,China;Department of Pharmaceutics,School of Pharmacy,China Pharmaceutical University,Nanjing 211198,China;NMPA Key Laboratory for Research and Evaluation of Pharmaceutical Preparations and Excipients,China Pharmaceutical University,Nanjing 210009,China;School of Basic Medicine and Clinical Pharmacy,China Pharmaceutical University,Nanjing 211198,China;Jiangsu Provincial Key Laboratory of Drug Metabolism and Pharmacokinetics,Nanjing 210009,China)

机构地区：[1]中国药科大学多靶标天然药物全国重点实验室,江苏南京211198 [2]中国药科大学药学院药剂系,江苏南京211198 [3]国家药品监督管理局药物制剂及辅料研究与评价重点实验室,江苏南京210009 [4]中国药科大学基础医学与临床药学学院,江苏南京211198 [5]江苏省药物代谢动力学重点实验室,江苏南京210009

出　　处：《药学研究》2025年第2期155-164,共10页Journal of Pharmaceutical Research

基　　金：国家自然科学基金青年项目(No.82303820)。

摘　　要：近年来肿瘤免疫治疗取得了突破性进展。肿瘤疫苗通过增强免疫原性,克服免疫抑制,从而激活自身免疫识别并杀灭肿瘤细胞,是一种极具前景的免疫疗法。仿生型细胞膜纳米囊泡具有肿瘤特异性靶向、延长体内半衰期以及免疫激活效果等优势,为肿瘤疫苗的设计开辟了新思路。本文综述了近年细胞膜纳米囊泡在肿瘤疫苗方面的研究进展,总结了细胞膜纳米囊泡的特点、制备与表征方法和修饰手段,并对细胞膜纳米囊泡在临床应用中面临的挑战进行分析。In recent years,breakthroughs have been made in tumor immunotherapy.Tumor vaccines can overcome immunosuppression by enhancing immunogenicity,thereby activating immunity to recognize and kill tumor cells,which is a promising immunotherapy modality.Biomimetic cellular membrane nanovesicles with the advantages of tumor specific targeting,prolonged half-life and immune activation effects have potential to flourish the design of tumor vaccines.In this review,we summarized the recent progresses of various cellular membrane nanovesicles in the application of tumor vaccines,discussed their characteristics,preparation,characterization and modification methods,and analyzed the challenges in clinical application.

关 键 词：肿瘤免疫治疗 肿瘤疫苗 细胞膜纳米囊泡 药物递送系统 

分 类 号：R730.1[医药卫生—肿瘤]