微生物-肠-脑轴在精神疾病中的研究进展  

Research Progress on the Microbe-gut-brain Axis in Psychiatric Disorders

作　　者：张月美 贾含香 郭蒙 夏雨晴 杨宁 周泓 王军[1,2,3,4] ZHANG Yuemei;JIA Hanxiang;GUO Meng;XIA Yuqing;YANG Ning;ZHOU Hong;WANG Jun(Cooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province),Hubei University of Technology,Wuhan 430068,China;Cell Regulation and Molecular Pharmacy Innovation Introduction Base(“111 Base”),Hubei University of Technology,Wuhan 430068,China;Institute for Diagnosis and Intervention of Autism and Depression,Hubei University of Technology,Wuhan 430068,China;International Joint Research Center for Health and Precision Medicine and Nutrition,Hubei University of Technology,Wuhan 430068,China)

机构地区：[1]湖北工业大学工业发酵省部共建协同创新中心,湖北武汉430068 [2]湖北工业大学细胞调控与分子药物学科创新引智基地(“111基地”),湖北武汉430068 [3]湖北工业大学孤独症抑郁症诊断与干预研究所,湖北武汉430068 [4]湖北工业大学大健康与精准医药营养国际联合研究中心,湖北武汉430068

出　　处：《工业微生物》2025年第1期116-124,共9页Industrial Microbiology

基　　金：国家自然科学基金(编号:82061138005);湖北省教育厅创新团队项目(编号:T2020009)。

摘　　要：肠道菌群已被发现可通过微生物-肠-脑轴与大脑之间的相互作用,对各种生理过程进行调节。同时,微生物-肠-脑轴在抑郁症、孤独症谱系障碍、双相情感障碍、雷特综合征和注意缺失障碍等精神疾病中具有显著作用。在此背景下,文章就微生物-肠-脑轴在精神疾病中的研究进展进行综述,并展望了该领域未来的发展方向。Gut flora has been found to regulate various physiological processes through the interaction between the brain and the microbe-gut-brain axis.The role of the microbe-gut-brain axis in psychiatric disorders,including depression,autism spectrum disorder,bipolar disorder,Rett syndrome,and attention deficit disorder is significant.Based on this,the article provides a review of the research progress of the microbe-gut-brain axis in psychiatric disorders and discusses future perspectives of the field.

关 键 词：抑郁症 孤独症谱系障碍 双相情感障碍 雷特综合征 注意缺陷障碍 微生物-肠-脑轴 肠道菌群 

分 类 号：R749[医药卫生—神经病学与精神病学]