猪脱细胞真皮基质口腔修复膜的制备与性能分析  

Analysis for the Preparation and Performance of Porcine Acellular Dermal Matrix Oral Repair Membrane

作　　者：王凯[1] 杨波[1] 杨光[1] 郭志想 陈小红[2] WANG Kai;YANG Bo;YANG Guang;GUO Zhixiang;CHEN Xiaohong(School of Health Science and Engineering,University of Shanghai for Science and Technology,Shanghai 200093,China;School of Materials and Chemistry,University of Shanghai for Science and Technology,Shanghai 200093,China)

机构地区：[1]上海理工大学健康科学与工程学院,上海200093 [2]上海理工大学材料科学与工程学院,上海200093

出　　处：《工业微生物》2025年第1期161-167,共7页Industrial Microbiology

摘　　要：脱细胞真皮基质口腔修复膜是临床上用于引导骨再生、促进伤口修复的生物膜产品。然而,目前常用的修复膜存在性能较差的问题,难以满足临床需求。为此,文章通过涂布法与真空热干燥法相结合的方式,在不破坏脱细胞真皮基质的前提下,将修复膜设计为双层结构,并探究不同浓度促骨因子对修复膜性能的影响。结果表明,研究所制备的修复膜具有双面不同结构,在钙磷比为1.6时,样品抗张强度为80.38 MPa,断裂拉伸率为118%,降解时间为42 d,孔隙率为82.74%,吸湿率为437%,且具备良好的生物相容性,与其他临床产品相比性能提升较大。Acellular dermal matrix(ADM)oral repair membranes are biomembrane products clinically used to guide bone regeneration and promote wound healing.However,the performance of currently available repair membranes is suboptimal,and is difficult to meet clinical demands.Therefore,the article designs a bilayer structure for the repair membrane without the destruction of the ADM by combining the coating method with vacuum drying,and investigates the influence of different concentrations of osteogenic factors on the performance of the repair membrane.The results demonstrate that the repair membrane prepared by the research possessed a bilayer structure that the both side are different.When the Ca/P ratio is 1.6,the sample exhibites a tensile strength of 80.38 MPa,an elongation at break of 118%,a degradation time of 42 days,a porosity of 82.74%,and a moisture absorption rate of 437%.Furthermore,the membrane demonstrate excellent biocompatibility.Compared to other clinical products,the performance of this repair membrane is significantly enhanced.

关 键 词：猪脱细胞真皮基质 口腔修复膜 槲皮素 钙磷比 

分 类 号：R783.1[医药卫生—口腔医学]