小胶质细胞自噬在围手术期神经认知障碍中的研究进展  

Research progress of microglial autophagy in postoperative cognitive dysfunction

作　　者：宋婉莹 李成龙 丛玉双 戚思华[1] Song Wanying;Li Chenglong;Cong Yushuang;Qi Sihua(Department of Anesthesiology,the Fourth Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第四医院麻醉科,哈尔滨150001

出　　处：《国际麻醉学与复苏杂志》2025年第1期111-114,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(82271207)。

摘　　要：围手术期神经认知障碍(PND)是一种常见的麻醉及手术相关并发症,可增加围手术期患者的病死率。小胶质细胞自噬作为一种溶酶体降解途径,在PND中发挥重要作用。文章主要阐述小胶质细胞自噬通过调节表型极化和神经炎症等方面对PND的保护作用,对既往关于小胶质细胞自噬与PND的临床研究与基础研究进行综述,总结其在相关研究中涉及的保护机制,以期为PND的防治提供新的思路与参考。Perioperative neurocognitive disorders(PND)are common complications associated with anesthesia and surgery,significantly increasing perioperative morbidity and mortality.Microglial autophagy,a crucial lysosomal degradation pathway,plays an essential role in PND.This article focuses on the protective effects of microglial autophagy on PND,highlighting its regulation of phenotypic polarization and neuroinflammation.It reviews both clinical and fundamental studies related to microglial autophagy and PND,summarizing the protective mechanisms identified in relevant investigations.The aim is to provide novel insights and references for the prevention and treatment of PND.

关 键 词：围手术期神经认知障碍 小胶质细胞 自噬 

分 类 号：R74[医药卫生—神经病学与精神病学]