Light-responsive nanomaterials for biofilm removal in root canal treatment  

作　　者：Di An Mingdong She Ziyang Zhang Ting Zhang Miaomiao Xu Jinjun Shao Qian Shen Xuna Tang 

机构地区：[1]Key Laboratory of Flexible Electronics(KLOFE)&Institute of Advanced Materials(IAM),Nanjing Tech University,Nanjing 210009,China [2]Department of Senior Expert Diagnosis and Treatment Center,Nanjing Stomatological Hospital,Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,China [3]State Key Laboratory of Organic Electronics and Information Displays&Jiangsu Key Laboratory for Biosensors,Institute of Advanced Materials(IAM),Nanjing University of Posts and Telecommunications,Nanjing 210023,China

出　　处：《Chinese Chemical Letters》2025年第2期10-20,共11页中国化学快报(英文版)

基　　金：supported by the Natural Science Foundation of Jiangsu Province(No.BK20200092)。

摘　　要：Various chemical irrigants and drugs have been employed for intra-canal disinfection in root canal therapy(RCT).However,due to the complexity of root canal anatomy,many drugs still exhibit poor penetrability and antibiotic resistance,leading to suboptimal treatment outcomes.Thus,it is challenging to remove the organic biofilms from root canals.In recent years,light-responsive therapy,with deeper tissue penetration than traditional treatments,has emerged as an effective RCT modality.Herein,this review summarizes the recent development of light-responsive nanomaterials for biofilm removal in RCT.The light-responsive nanomaterials and the corresponding therapeutic methods in RCT,including photodynamic therapy(PDT),photothermal therapy(PTT),and laser-activated therapy,are highlighted.Finally,the challenges that light-responsive nanomaterials and treatment modalities will encounter to conquer the biofilm in future RCT are discussed.This review is believed to significantly accelerate the future development of light-responsive nanomaterials for RCT from bench to bedside.

关 键 词：Light-responsive nanomaterials BIOFILM Root canal treatment Photodynamic therapy Photothermal therapy 

分 类 号：R783.1[医药卫生—口腔医学] TB383.1[医药卫生—临床医学]