Engineered iron-based metal-organic frameworks nanoplatforms for cancer theranostics:A mini review  

作　　者：Yunlong Li Xinyu Zhang Shuang Liu Chunsheng Li Qiang Wang Jin Ye Yong Lu Jiating Xu 

机构地区：[1]Key Laboratory of Forest Plant Ecology,Ministry of Education,College of Chemistry,Chemical Engineering and Resource Utilization,Northeast Forestry University,Harbin 150040,China [2]Heilongjiang Provincial Key Laboratory of Ecological Utilization of Forestry-Based Active Substances,Northeast Forestry University,Harbin 150040,China [3]School of Laboratory Medicine,Wannan Medical College,Wuhu 241002,China

出　　处：《Chinese Chemical Letters》2025年第2期52-65,共14页中国化学快报(英文版)

基　　金：National Key Research and Development Program of China(No.2022YFD2200602);111 Project(No.B20088);National Natural Science Foundation of China(Nos.52202345 and 31930076);the Heilongjiang Touyan Innovation Team Program(Tree Genetics and Breeding Innovation Team)。

摘　　要：Up to now,numerous emerging methods of cancer treatment including chemodynamic therapy,photothermal therapy,photodynamic therapy,sonodynamic therapy,immunotherapy and chemotherapy have rapidly entered a new stage of development.However,the single treatment mode is often constrained by the complex tumor microenvironment.Recently,the nanomaterials and nanomedicine have emerged as promising avenues to overcome the limitation in cancer theranostics.Especially,metal-organic frameworks(MOFs)have gained considerable interests in cancer therapy because of their customizable morphologies,easy functionalization,large specific surface area,and good biocompatibility.Among these MOFs,iron-based MOFs(Fe-MOFs)are particularly promising for cancer treatment due to their properties as nano-photosensitizers,peroxidase-like activity,bioimaging contrast capabilities,and biodegradability.Utilizing their structural regularity and synthetic tunability,Fe-MOFs can be engineered to incorporate organic molecules or other inorganic nanoparticles,thereby creating multifunctional nanoplatforms for single or combined theranostic modes.Herein,the minireview focuses on the recent advancements of the Fe-MOFs-based nanoplatforms for self-enhanced imaging and treatment at tumor sites.Furthermore,the clinical research development of Fe-MOFs-based nanoplatforms is discussed,addressing key challenges and innovations for the future.Our review aims to provide novice researchers with a foundational understanding of advanced cancer theranostic modes and promote their clinical applications through the modification of Fe-MOFs.

关 键 词：BIOIMAGING Cancer theranostics Catalytic therapy Engineered nanoplatforms Fe-based MOFs 

分 类 号：R730.5[医药卫生—肿瘤] O641.4[医药卫生—临床医学] TB383.1[理学—物理化学]