Oscillatory flow reactor facilitates fast photochemical Wolff rearrangement toward synthesis ofα-substituted amides in flow  

作　　者：Huashan Huang Jingze Chen Luyun Zhang Hong Yan Siqi Li Fen-Er Chen 

机构地区：[1]Institute of Pharmaceutical Science and Technology,College of Chemistry,Fuzhou University,Fuzhou 350108,China [2]Key Laboratory of Natural Medicines of the Changbai Mountain,Ministry of Education,Molecular Medicine Research Center,College of Pharmacy,Yanbian University,Yanji 133002,China [3]Engineering Center of Catalysis and Synthesis for Chiral Molecules,Department of Chemistry,Fudan University,Shanghai 200433,China [4]Shanghai Engineering Center of Industrial Catalysis for Chiral Drugs,Shanghai 200433,China

出　　处：《Chinese Chemical Letters》2025年第2期361-365,共5页中国化学快报(英文版)

基　　金：financial support from the National Natural Science Foundation of China(No.22208279);Financial support from the Fuzhou University(No.0041/511095)。

摘　　要：A visible light-promoted fast photochemical Wolff rearrangement was developed toward synthesis ofα-substituted amides in continuous flow with the use of a photochemical oscillatory flow reactor(POFR).The control experiment indicates that a fast process of the Wolff rearrangement(<40 s)is involved.Notably,this protocol does not require excess use of any reactants,and the resultingα-substituted amides could be isolated by recrystallization in good to excellent yields.

关 键 词：Flow photochemistry Oscillatory flow reactor Wolff rearrangement KETENE α-Substituted amides 

分 类 号：TQ225.261[化学工程—有机化工]