Nd@C_(3)N_(4)-photoredox/chlorine dual catalyzed synthesis and evaluation of antitumor activities of 4-alkylated sulfonyl ketimines  

作　　者：Hong-Tao Ji Yu-Han Lu Yan-Ting Liu Yu-Lin Huang Jiang-Feng Tian Feng Liu Yan-Yan Zeng Hai-Yan Yang Yong-Hong Zhang Wei-Min He 

机构地区：[1]Department of Ophthalmology,The Affiliated Nanhua Hospital,Hengyang Medical School,University of South China,Hengyang 421001,China [2]School of Chemistry and Chemical Engineering,University of South China,Hengyang 421001,China [3]Department of Lung Cancer and Gastroenterology,Hunan Cancer Hospital,The Affiliated Cancer Hospital of Xiangya School of Medicine,Central South University,Changsha 410013,China

出　　处：《Chinese Chemical Letters》2025年第2期384-388,共5页中国化学快报(英文版)

基　　金：supported by grants from the Provincial Natural Science Foundation of Hunan(No.2023JJ60335)。

摘　　要：The first example of Nd@C_(3)N_(4)-photoredox/chlorine dual catalyzed alkylation with unactivated alkanes as the alkyl sources has been developed,which allows for the synthesis of various 4-alkylated cyclic sulfonyl ketimines.In this process,chlorine functions as both a redox and hydrogen atom transfer catalyst.The synergism of the reversible Nd^(2+)/Nd^(3+)and Cl^(ˉ)/Cl˙redox pairs significantly enhances overall photocatalytic efficiency.The in vitro anticancer activity of 4-alkylated products was evaluated by using the CCK8assay against both human choroidal melanoma(MUM-2B)and lung cancer(A549)cell.Compound 3da showed approximately triple the potency of 5-fluorouracil.

关 键 词：Dual catalysis Semiconductor CHLORINE Redox catalyst Hydrogen atom transfer 

分 类 号：R730.5[医药卫生—肿瘤] TQ218[医药卫生—临床医学]