认知行为疗法配合丁螺环酮及舍曲林治疗伴焦虑症状抑郁症的临床效果  

Clinical effects of cognitive behavioral therapy combined with buspirone and sertraline in the treatment of depression with anxiety symptoms

作　　者：李庆 翟绍征 周文琼 曹杰 王敏林 LI Qing;ZHAI Shaozheng;ZHOU Wenqiong;CAO Jie;WANG Minlin(Department of Psychiatry,The Third People's Hospital of Yichun City,Yichun,Jiangxi,336000,China)

机构地区：[1]宜春市第三人民医院精神科,江西宜春336000

出　　处：《当代医学》2024年第25期84-88,共5页Contemporary Medicine

摘　　要：目的探讨认知行为疗法配合丁螺环酮及舍曲林治疗伴焦虑症状抑郁症的临床效果。方法选取2020年10月至2022年12月宜春市第三人民医院收治的70例伴焦虑症状的抑郁症患者作为研究对象,采用随机数字表法分为研究组与对照组,每组35例。对照组给予丁螺环酮联合舍曲林药物治疗,研究组在对照组基础上开展认知行为疗法干预。比较两组临床疗效、治疗前后血清因子[去甲肾上腺素(norepinephrine,NE)、5-羟色胺(5-ydroxytryptamine,5-HT)、多巴胺(dopamine,DA)]水平及不良反应发生情况。结果研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组NE、5-HT、DA水平比较差异无统计学意义;治疗后,两组NE、DA水平均低于治疗前,5-HT水平均高于治疗前,且研究组NE、DA水平均低于对照组,5-HT水平高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论认知行为疗法配合丁螺环酮及舍曲林治疗伴焦虑症状的抑郁症疗效显著,可改善患者血清因子水平,值得临床推广应用。Objective To investigate the clinical effect of cognitive behavioral therapy combined with buspirone and sertraline in the treatment of depression with anxiety symptoms.Methods A total of 70 depression patients with anxiety symptoms admitted to The Third People's Hospital of Yichun City from October 2020 to December 2022 were selected as the research subjects,and they were divided into the study group and the control group by random number table method,with 35 cases in each group.The control group was treated with buspirone combined with sertraline,while the study group was treated with cognitive behavioral therapy.The clinical efficacy,serum factors(norepinephrine[NE],5-ydroxytryptamine[5-HT],dopamine[DA])before and after treatment and the occurrence of adverse reactions were compared between the two groups.Results The total effective rate in the study group was higher than that in the control group,the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in serum NE,5-HT and DA levels between the two groups;after treatment,the levels of NE and DA of the two groups were lower than before treatment,and the level of 5-HT was higher than before treatment,and the serum levels of NE and DA in the study group were lower than that in the control group,and the level of 5-HT was higher than that in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups.Conclusion Cognitive behavioral therapy combined with buspirone and sertraline is effective in the treatment of depression patients with anxiety symptoms,and can improve the serum factor level of patients,which is worthy of clinical promotion and application.

关 键 词：抑郁症 焦虑症状 丁螺环酮 舍曲林 认知行为疗法 

分 类 号：R749.72[医药卫生—神经病学与精神病学]