昼夜节律基因调控消化系统肿瘤及中药干预作用的研究进展  

Research progress on circadian rhythm genes regulating digestive system tumors and the intervention of traditional Chinese medicine

作　　者：孙硕 张文洁 赵益[2] 孙有智[1] SUN Shuo;ZHANG Wenjie;ZHAO Yi;SUN Youzhi(College of Traditional Chinese Medicine·College of Life Sciences,Jiangxi University of Chinese Medicine,Nanchang 330004,Jiangxi,China;不详)

机构地区：[1]江西中医药大学中医学院·生命科学学院,江西南昌330004 [2]江西中医药大学中医基础理论分化发展研究中心,江西南昌330004

出　　处：《实用医学杂志》2025年第5期648-656,共9页The Journal of Practical Medicine

基　　金：国家自然科学基金项目(编号:82360961,82060868);江西省中医药骨干人才培养项目(编号:赣中医药科教字[2021]4号);江西省教育厅科学技术研究项目(编号:GJJ2200907);江西中医药大学校级科技创新团队发展计划(编号:CXTD22007,CXTD22008)。

摘　　要：昼夜节律,作为生物体长期进化以适应地球环境的结果,在生命活动中起着关键的调节作用。昼夜节律的紊乱已被确认为潜在的致癌风险因素,与消化系统疾病的病理状态紧密相关,并在消化系统肿瘤的发生与发展过程中起到了重要的作用,它不仅涉及到肿瘤细胞的周期调控、增殖、凋亡过程,还深刻影响着细胞的迁移能力、免疫功能以及耐药性的形成。本文聚焦于昼夜节律基因对消化系统肿瘤的具体调控机制,并综合概述了中药通过靶向这些生物钟基因以实现抗肿瘤效果的研究成果,以期为消化系统肿瘤的治疗提供新的靶点选择与预后评估途径。Circadian rhythms,a result of the long-term evolution of organisms adapting to the Earth′s environment,play a crucial regulatory role in biological activities.Disruptions in circadian rhythms have been identified as potential carcinogenic risk factors,closely linked to the pathological states of digestive system diseases,and significantly contribute to the occurrence and progression of digestive system tumors.These rhythms not only influence the regulation of cell cycles,proliferation,and apoptosis of tumor cells but also profoundly affect their migratory abilities,immune functions,and drug resistance.This article focuses on the specific regulatory mechanisms of circadian rhythm genes in relation to digestive system tumors and comprehensively summarizes research findings on the anti-tumor effects of traditional Chinese medicine targeting these circadian clock genes.The aim is to provide new avenues for target selection and prognostic evaluation in the treatment of digestive system tumors.

关 键 词：昼夜节律 生物钟基因 消化系统肿瘤 中药 机制 

分 类 号：R735[医药卫生—肿瘤]