子宫颈癌PAX1联合JAM3双基因甲基化检测流程、报告及临床应用专家共识  

Expert consensus on the workflow, report, and clinical applications of dual-gene methylation detection of PAX1 and JAM3 for cervical cancer

作　　者：中国中西医结合学会检验医学专业委员会 中华医学会检验医学分会 中国医师协会检验医师分会 中国妇幼保健协会 中国医疗保健国际交流促进会基层检验技术标准化分会 谢小兵[2] 李雷[3] 陈飞[3] 关明[4] 刘禹利 邱丽华[6] 汪俊军 Laboratory Medicine Committee of Chinese Association of Integrative Medicine;Chinese Society of Laboratory Medicine;Chinese Laboratory Physician Branch of Chinese Medical Doctor Association;China Maternal and Child Health Association;Xie Xiaobing;Li Lei

机构地区：[1]不详 [2]湖南中医药大学第一附属医院医学检验中心 [3]中国医学科学院北京协和医院妇产科 [4]复旦大学华山医院检验科 [5]广东药科大学附属第一医院精准医学中心 [6]上海交通大学医学院附属仁济医院妇产科 [7]东部战区总医院检验科

出　　处：《中华检验医学杂志》2025年第2期192-200,共9页Chinese Journal of Laboratory Medicine

摘　　要：基于子宫颈癌筛查现状以及筛查方法、策略的发展,中国中西医结合学会检验医学专业委员会联合4个学(协)会,组织检验、病理、妇产多学科专家共同制定了甲基化检测与临床应用的共识。共识全面梳理了PAX1联合JAM3双基因甲基化(PAX1m/JAM3m)检测的实验室操作流程及质控标准、样本采集与处理,提出了PAX1m/JAM3m检测意义及功能、实验室检测流程、质量控制、检测报告及临床应用建议。共识旨在推动子宫颈癌甲基化在实验室检测与临床的规范化应用,为检测结果的准确性和可靠性,并为明确临床应用场景,提供具备实践性与前瞻性的指导。Based on the current status of cervical cancer screening and the development of screening methods and strategies,Laboratory Medicine Committee of Chinese Association of Integrative Medicine collaborated with four academic(or professional)societies,involving multidisciplinary experts in laboratory testing,pathology,and obstetrics and gynecology,jointly formulated this expert consensus recommendations for methylation testing and clinical application of PAX1 and JAM3 for cervical cancer.This expert consensus thoroughly outlines the laboratory operational procedures and quality control standards for the PAX1 combined with JAM3 dual-gene methylation(PAX1 m/JAM3 m)testing,as well as specimen collection and handling.It discusses the significance and functionality of PAX1 m/JAM3 m testing,the laboratory testing process,quality control,testing reports,and provides detailed clinical application suggestions.The aim of this expert consensus is to promote the standardized application of cervical cancer methylation testing in laboratories and clinical settings,ensuring the accuracy and reliability of test results,clarifying clinical application scenarios,and providing practical and forward-looking guidance.

关 键 词：子宫颈癌 DNA甲基化 临床实验室技术 临床应用 共识 

分 类 号：R737.33[医药卫生—肿瘤]